Atypical HIV-vacuolar myelopathy: a case report.

Tau Mongezi, Joseph Sibi, George Jerry, Ibañez-Valdés Lourdes de Fátima, Dubula Tozama, Foyaca Sibat Humberto

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In one paragraph

Article in European journal of medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.9field-weighted citation impact, top 33% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

HIV-Associated Vacuolar Myelopathy and HIV-Associated Neurocognitive Disorder as an Initial Presentation in HIV Infection.Case reports in infectious diseases · 2023
Article
The utility of diffusion-weighted imaging in patients with spinal cord infarction: difference from the findings of neuromyelitis optica spectrum disorder.BMC neurology · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tau MongeziDepartment of Internal Medicine, Nelson Mandela Academic Central Hospital (NMACH), Walter Sisulu University, Mthatha, South Africa.

Joseph SibiDivision of Neurology, NMACH, Walter Sisulu University, Mthatha, South Africa.ORCID http://orcid.org/0000-0002-6747-7933

George JerryDivision of Neurology, NMACH, Walter Sisulu University, Mthatha, South Africa.ORCID http://orcid.org/0000-0003-3493-2482

Ibañez-Valdés Lourdes de FátimaDivision of Neurology, NMACH, Walter Sisulu University, Mthatha, South Africa.ORCID http://orcid.org/0000-0002-2692-1348

Dubula TozamaDepartment of Medicine, and Division of Internal Medicine, Water Sisulu University (WSU), Mthatha, South Africa.ORCID http://orcid.org/0000-0001-6896-8614

Foyaca Sibat HumbertoDivision of Neurology, NMACH, Walter Sisulu University, Mthatha, South Africa. humbertofoyacasibat@gmail.com.ORCID http://orcid.org/0000-0002-6023-2394

Walter Sisulu University · ZANelson Mandela Academic Hospital · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHere, we report an atypical HIV-vacuolar myelopathy and search the available medical literature about atypical presentations of human immunodeficiency virus associate vacuolar myelopathy (HIV-VM) and immunoglobulin therapy response. CASE: A 26-year-old lady who was 4 weeks postpartum presented to us with acute flaccid quadriparesis, with no sensory level. Extensive workup ruled out other causes of myelopathy. She developed a stage 3 acute kidney injury, and MRI showed diffuse cord atrophy involving the lower cervical and thoracic cord. The patient received IV-immunoglobulin, ARVs, and supportive therapy with inadequate response. Unfortunately, she developed nosocomial pneumonia and died. DISCUSSION: In HIV-VM, there is spinal cord atrophy, which mainly involves the thoracic cord. In our case, this pathological process also affected the spinal cord's cervical region, leading to flaccid tetraplegia, with high CD4 level, without response to the treatment, including intravenous immunoglobulin. KEYNOTES: Vacuolar myelopathy, HIV, Immunoglobulin therapy, flaccid tetraplegia, hypokalaemia. Renal failure.

Indexed as

AdultFemaleHIV InfectionsHumansSpinal Cord DiseasesAssociated lesions of the nervous systemCase reportHIV-vacuolar myelopathyHuman immunodeficiency virusHuman immunodeficiency virus-associated myelopathyIntravenous immunoglobulin administration

Identifiers

PMID33522960

DOI10.1186/s40001-021-00483-0

PMCPMC7851951

OpenAlexW3128371169

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.