ArticleArthritis research & therapy2021
Changes in the proportion of clinical clusters contribute to the phenotypic evolution of Behçet's disease in Japan.
Article in Arthritis research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Epidemiology and clinical features of Behçet's disease in the Middle East and North Africa:A systematic review and meta-analysis.Clinical rheumatology · 2026Pooled it
- Behçet's Disease: A Comprehensive Review on the Role ofInternational journal of molecular sciences · 2023Pooled it
- Efficacy and safety of low-dose interleukin 2 for Behçet's syndrome: a randomized, placebo-controlled, double-blind, phase 2 clinical trial.Nature communications · 2026Trial
- Identification of distinct subgroups in Chinese patients with Behçet's syndrome via cluster analysis of immune cells and clinical features.Arthritis research & therapy · 2026Article
- Case Report: From idiopathic recurrent pericarditis to systemic Behçet's Disease: unmasking a unified IL-1-driven autoinflammatory phenotype.Frontiers in immunology · 2026Article
- Risk of intestinal involvement in mucocutaneous-onset Behçet's disease: data from the AIDA network registry.Frontiers in immunology · 2026Article
- Towards a basis for vascular versus intestinal phenotype differences; East Meets West in Behcet's disease.Frontiers in immunology · 2026Review
- Identification of markers predicting clinical course in patients with Behcet disease by combination of machine learning and unbiased clustering analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Cluster and correspondence analyses for oral ulcer activity related factors in Behçet's syndrome.Medicina oral, patologia oral y cirugia bucal · 2025Article
- Clinical Features and Phenotypic Similarities of Patients with Familial Behçet's Disease.European journal of rheumatology · 2025Article
- Article
- HLA-B5 prevalence in patients with spondyloarthritis and impact on disease phenotype: a multicentric case-control study.Rheumatology (Oxford, England) · 2025Observational
- Multisystemic Manifestations of Behcet's Disease and Its Treatment Outcome: A Case Report and Review of the Literature.Clinical case reports · 2025Article
- Behçet's disease: incidence, prevalence, and real-word data on the use of biologic agents in Japan.Journal of gastroenterology · 2025Observational
- Assessing disease phenotypes in Behçet's syndrome: insights from a multiple correspondence analysis.Frontiers in immunology · 2025Article
- Clinical characteristics and quality of life of patients with Behcet's disease with arthritis in Japan.Scientific reports · 2024Article
- Gender disparities in Behçet's syndrome: identifying distinct phenotypes through cluster analysis.Immunologic research · 2024Article
- Clinical phenotypes of adult-onset Behçet's syndrome: a comprehensive cross-sectional study in China.Clinical rheumatology · 2024Article
- Decoding Behcet's Uveitis: an In-depth review of pathogenesis and therapeutic advances.Journal of neuroinflammation · 2024Review
- Behçet's syndrome: recent advances to aid diagnosis.Clinical and experimental medicine · 2023Review
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15 authors at 7 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundWe hypothesized that Behçet's disease (BD) consists of several clinical subtypes with different severity, resulting in heterogeneity of the disease. Here, we conducted a study to identify clinical clusters of BD.
methodsA total of 657 patients registered in the Yokohama City University (YCU) regional BD registry between 1990 and 2018, as well as 6754 patients who were initially registered in the Japanese Ministry of Health, Labour and Welfare (MHLW) database between 2003 and 2014, were investigated. The YCU registry data regarding the clinical manifestations of BD, human leukocyte antigen (HLA) status, treatments, and hospitalizations were analyzed first, followed by similar analyses of the MHLW for validation. A hierarchical cluster analysis was independently performed in both patient groups.
resultsA hierarchical cluster analysis determined five independent clinical clusters in the YCU cohort. Individual counterparts of the YCU clusters were confirmed in the MHLW registry. Recent phenotypical evolutions of BD in Japan, such as increased gastrointestinal (GI) involvement, reduced complete type according to the Japan Criteria, and reduced HLA-B51 positivity were associated with chronologically changing proportions of the clinical clusters.
conclusionsIn this study, we identified independent clinical clusters among BD patients in Japan and found that the proportion of each cluster varied over time. We propose five independent clusters namely "mucocutaneous", "mucocutaneous with arthritis", "neuro", "GI", and "eye."
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