Evidence map›Paper›PMID 33522711›Full record

ArticlePigment cell & melanoma research2021

Multiple desmoplastic Spitz nevi with BRAF fusions in a patient with ring chromosome 7 syndrome.

Simon F Roy, Boris C Bastian, Sheilagh Maguiness, Alessio Giubellino, Swapna S Vemula, Timothy H McCalmont, Iwei Yeh

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pigment cell & melanoma research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Gene fusions in melanocytic lesions: an updated comprehensive review.Journal of pathology and translational medicine · 2026
    Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Simon F RoyDepartment of Pathology, University of Montréal, Montréal, OC, Canada.ORCID 0000-0002-5444-0349
Boris C BastianDepartment of Dermatology, University of California in San Francisco, San Francisco, CA, USA.ORCID 0000-0003-1836-6062
Sheilagh MaguinessDepartment of Dermatology, University of Minnesota, Minneapolis, MN, USA.
Alessio GiubellinoDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Swapna S VemulaDepartment of Pathology, University of California in San Francisco, San Francisco, CA, USA.
Timothy H McCalmontDepartment of Dermatology, University of California in San Francisco, San Francisco, CA, USA.
Iwei YehDepartment of Dermatology, University of California in San Francisco, San Francisco, CA, USA.ORCID 0000-0002-3941-3561
University of California, San Francisco · USUniversity of Minnesota · USUniversité de Montréal · CA

Funding

Molecular and immunologic evolution of melanomas from pre-neoplastic lesionsR35CA220481 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BASTIAN, BORIS C. · 2017 to 2023
$6.3M
NCI NIH HHS R35 CA220481
6 · The paper itself

Abstract

Patients with non-supernumerary ring chromosome 7 syndrome have an increased incidence of hemangiomas, café-au-lait spots, and melanocytic nevi. The mechanism for the increased incidence of these benign neoplasms is unknown. We present the case of a 22-year-old man with ring chromosome 7 and multiple melanocytic nevi. Two nevi, one on the right ear and the other on the right knee, were biopsied and diagnosed as desmoplastic Spitz nevi. Upon targeted next-generation DNA sequencing, both harbored BRAF fusions. Copy number alterations and fluorescence in situ hybridization (FISH) for BRAF suggested that the fusions arose on the ring chromosome 7. Hence, one reason for increased numbers of nevi in patients with non-supernumerary ring chromosome 7 syndrome may be increased likelihood of BRAF fusions, due to the instability of the ring chromosome.

Indexed as

Chromosome DisordersEar NeoplasmsNevus, Epithelioid and Spindle CellOncogene Proteins, FusionProto-Oncogene Proteins B-rafRing ChromosomesSkin NeoplasmsAdultChromosomes, Human, Pair 7HumansMaleBRAF protein, humanOncogene Proteins, FusionProto-Oncogene Proteins B-rafBRAF fusionBRAF genemelanocytic nevimelanocytic nevusring chromosome 7ring chromosome sevenSpitz nevusspitzoidSpitz tumor

Identifiers

PMID33522711
PMCPMC9351601
OpenAlexW3127381100

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.