Evidence map›Paper›PMID 33522683›Full record

ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging2021

Microstructural Changes in the Left Mesocorticolimbic Pathway are Associated with the Comorbid Development of Fatigue and Depression in Multiple Sclerosis.

Miklos Palotai, Catherine Small, Nikolaos Makris, Nathaniel G Somes, Alfredo Morales Pinzon, Yogesh Rathi, Aldo Marzullo, James J Levitt, Rohit Bakshi, Tanuja Chitnis and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Depression and anxiety in multiple sclerosis. Review of a fatal combination.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
  3. Article
  4. Observational
  5. Review
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Miklos PalotaiCenter for Neurological Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0003-0268-6977
Catherine SmallCenter for Neurological Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Nikolaos MakrisPsychiatry Neuroimaging Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Nathaniel G SomesPsychiatry Neuroimaging Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Alfredo Morales PinzonCenter for Neurological Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Yogesh RathiPsychiatry Neuroimaging Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Aldo MarzulloDepartment of Mathematics and Computer Science, University of Calabria, Rende, Italy.
James J LevittPsychiatry Neuroimaging Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Rohit BakshiPartners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0001-8601-5534
Tanuja ChitnisPartners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Charles R G GuttmannCenter for Neurological Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Brigham and Women's Hospital · USUniversity of Calabria · IT

Funding

Neural substrates of diffusion imaging in cognitively aging rhesus monkeysR01AG042512 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK, MAKRIS, NIKOLAOS · 2013 to 2023
$6.5M
High Resolution, Comprehensive Atlases of the Human Brain MorphologyR01MH112748 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI BOUIX, SYLVAIN, KUBICKI, MAREK · 2018 to 2022
$4.1M
Mechanisms of myelin damage and cognitive impairment in the aging monkey: Gene Expression, Neurophysiology, Inflammation and Effects of Calorie RestrictionRF1AG043640 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENE, DOUGLAS L · 2019 to 2019
$3.7M
Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey BrainR01AG043640 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENE, DOUGLAS L · 2013 to 2017
$3.0M
Patient-specific, Effective, and Rational Functional Connectivity Targeting for DBS in OCDR01MH111917 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DOUGHERTY, DARIN D, MAKRIS, NIKOLAOS · 2017 to 2019
$2.1M
Mentoring and neuroimaging research on new targets for DBS in OCDK24MH116366 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MAKRIS, NIKOLAOS · 2018 to 2022
$817k
The Brain Wiring of Frontostriatal Connections in Early PsychosisR21MH121704 · NIMH · HARVARD MEDICAL SCHOOL · PI LEVITT, JAMES JONATHAN · 2020 to 2021
$429k
NIA NIH HHS R01 AG042512NIA NIH HHS R01 AG043640NIA NIH HHS RF1 AG043640NIMH NIH HHS K24 MH116366NIMH NIH HHS R01 MH111917NIMH NIH HHS R01 MH112748NIMH NIH HHS R21 MH121704
6 · The paper itself

Abstract

background and purposeLower reward responsiveness has been associated with fatigue in multiple sclerosis (MS). However, association of MS-related fatigue with damage to the mesocorticolimbic reward pathway (superolateral medial forebrain bundle [slMFB]) has not been assessed. We investigated the association of fatigue and depression with slMFB damage in MS patients stratified based on longitudinal fatigue patterns.

methodsPatient stratification: 1. Sustained Fatigue (SF): latest two Modified Fatigue Impact Scale (MFIS) ≥ 38 (n = 26); 2. Reversible Fatigue (RF): latest MFIS < 38, and at least one previous MFIS ≥ 38 (n = 25); 3. Never Fatigued (NF): ≥ 5 consecutive MFIS < 38 (n = 42); 4. Healthy Controls (n = 6). Diffusion MRI-derived measures of fractional anisotropy (FA), axial (AD), mean (MD), and radial diffusivity (RD) of the slMFB were compared between the groups. Depression was assessed using the Center for Epidemiologic Studies-Depression Scale (CES-D).

resultsDepressed (CES-D ≥ 16) SF patients showed significantly higher MD and RD than nondepressed SF and RF, and depressed RF patients, and significantly lower FA than nondepressed SF and depressed RF patients in their left slMFB. Depressed SF patients showed significantly higher left slMFB MD and AD than healthy controls.

conclusionMicrostructural changes to the left slMFB may play a role in the comorbid development of fatigue and depression in MS.

Indexed as

AdultAnisotropyDepressionDiffusion Magnetic Resonance ImagingFatigueFemaleHumansMaleMedial Forebrain BundleMiddle AgedMultiple Sclerosisdepressionfatiguemedial forebrain bundleMultiple sclerosisreward

Identifiers

PMID33522683
PMCPMC8119307
OpenAlexW3127212536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.