ArticleHuman brain mapping2021
Altered brain functional network dynamics in obsessive-compulsive disorder.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies.Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Changes in Brain Network Connections After Exposure and Response Prevention Therapy for Obsessive-Compulsive Disorder in Adolescents and Adults.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Trial
- Evaluating clinical and neuroimaging predictors for cognitive-behavioral therapy outcome in obsessive-compulsive disorder.Scientific reports · 2026Article
- Neurochemically informed network control theory reveals energetic dysregulation of altered brain state dynamics in obsessive-compulsive disorder.Psychiatry and clinical neurosciences · 2026Article
- Functional connectivity changes in obsessive-compulsive disorder following exposure and response prevention.Translational psychiatry · 2026Article
- Subtyping OCD based on individual symptom networks: subtype-specific neural dynamics and morphometric similarity linked to molecular profiles.Molecular psychiatry · 2026Article
- The role of the subcortical structures in subthreshold depression: evidence from static and dynamic functional connectivity.Brain structure & function · 2026Article
- Characterizing the relationship between functional network dynamics and the body mass index.Frontiers in nutrition · 2026Article
- Sex Similarities and Differences in Brain Dynamic Functional Connectivity Among Individuals With and Without Autism Spectrum Disorders.Human brain mapping · 2025Article
- Abnormal intrinsic brain functional network dynamics in delayed encephalopathy after carbon monoxide poisoning.Scientific reports · 2025Article
- Decreased inter- and intra-network connectivity after group cognitive behavioral therapy in patients with unmedicated obsessive-compulsive disorder.World journal of psychiatry · 2025Article
- Dysregulated connectivity configuration of triple-network model in obsessive-compulsive disorder.Molecular psychiatry · 2025Article
- Sex-specific brain morphological and network differences in patients showing Parkinson's disease with and without possible rapid eye movement sleep behavior disorder.Frontiers in neurology · 2025Article
- Age-related changes of node degree in the multiple-demand network predict fluid intelligence.IBRO neuroscience reports · 2024Article
- Alterations in spatiotemporal characteristics of dynamic networks in juvenile myoclonic epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Abnormal large-scale brain functional network dynamics in social anxiety disorder.CNS neuroscience & therapeutics · 2024Article
- The brain entropy dynamics in resting state.Frontiers in neuroscience · 2024Article
- Structural and functional alterations in the brains of patients with anisometropic and strabismic amblyopia: a systematic review of magnetic resonance imaging studies.Neural regeneration research · 2023Article
- Shared and Disorder-Specific Alterations of Brain Temporal Dynamics in Obsessive-Compulsive Disorder and Schizophrenia.Schizophrenia bulletin · 2023Article
- Balance-energy of resting state network in obsessive-compulsive disorder.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obsessive-compulsive disorder (OCD) is a debilitating and disabling neuropsychiatric disorder, whose neurobiological basis remains unclear. Although traditional static resting-state magnetic resonance imaging (rfMRI) studies have found aberrant functional connectivity (FC) in OCD, alterations in whole-brain FC and topological properties in the context of brain dynamics remain relatively unexplored. The rfMRI data of 29 patients with OCD and 40 healthy controls were analyzed using group independent component analysis to obtain independent components (ICs) and a sliding-window approach to generate dynamic functional connectivity (dFC) matrices. dFC patterns were clustered into three reoccurring states, and state transition metrics were obtained. Then, graph-theory methods were applied to dFC matrices to calculate the variability of network topological organization. The occurrence of a state (State 1) with the highest modularity index and lowest mean FC between networks was increased significantly in OCD, and the fractional time in brain State 1 was positively correlated with anxiety level in patients. State 1 was characterized by having positive connections within default mode (DMN) and salience networks (SAN), and negative coupling between the two networks. Additionally, ICs belonging to DMN and SAN showed lower temporal variability of nodal degree centrality and efficiency in patients, which was related to longer illness duration and higher current obsession ratings. Our results provide evidence of clinically relevant aberrant dynamic brain activity in OCD. Increased functional segregation among networks and impaired functional flexibility in connections among brain regions in DMN and SAN may play important roles in the neuropathology of OCD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.