Evidence map›Paper›PMID 33522489›Full record

ArticleeLife2021

In-host population dynamics of

Roger Vargas, Luca Freschi, Maximillian Marin, L Elaine Epperson, Melissa Smith, Irina Oussenko, David Durbin, Michael Strong, Max Salfinger, Maha Reda Farhat

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Loss of theScience advances · 2025
    Article
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  14. Whole-Genome Sequence-Based Diversity ofPathogens (Basel, Switzerland) · 2025
    Article
  15. Review
  16. Article
  17. The PE/PPE family proteins ofFrontiers in immunology · 2025
    Review
  18. Within-host population dynamics of extensively drug-resistantEvolution, medicine, and public health · 2025
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Roger VargasDepartment of Systems Biology, Harvard Medical School, Boston, United States.ORCID 0000-0002-7116-5211
Luca FreschiDepartment of Biomedical Informatics, Harvard Medical School, Boston, United States.
Maximillian MarinDepartment of Systems Biology, Harvard Medical School, Boston, United States.
L Elaine EppersonCenter for Genes, Environment and Health, Center for Genes, National Jewish Health, Denver, United States.
Melissa SmithDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, United States.
Irina OussenkoIcahn Institute of Data Sciences and Genomics Technology, New York, United States.
David DurbinMycobacteriology Reference Laboratory, Advanced Diagnostic Laboratories, National Jewish Health, Denver, United States.
Michael StrongCenter for Genes, Environment and Health, Center for Genes, National Jewish Health, Denver, United States.
Max SalfingerCollege of Public Health, University of South Florida, Tampa, United States.
Maha Reda FarhatDepartment of Biomedical Informatics, Harvard Medical School, Boston, United States.
Harvard University · USNational Jewish Health · USIcahn School of Medicine at Mount Sinai · USUniversity of South Florida · US

Funding

Investigating bacterial contributions to TB treatment response: a focus on in-host pathogen dynamicsR01AI155765 · NIAID · HARVARD MEDICAL SCHOOL · PI FARHAT, MAHA · 2020 to 2024
$3.7M
New Tools for the interpretation of Pathogen Genomic Data with a focus on Mycobacterium tuberculosisK01ES026835 · NIEHS · MASSACHUSETTS GENERAL HOSPITAL · PI FARHAT, MAHA · 2015 to 2019
$1.1M
NIAID NIH HHS R01 AI155765NIEHS NIH HHS K01 ES026835
6 · The paper itself

Abstract

Tuberculosis (TB) is a leading cause of death globally. Understanding the population dynamics of TB's causative agent

Indexed as

Drug Resistance, BacterialGenetics, PopulationHumansImmunity, InnateMycobacterium tuberculosisPhylogenyPolymorphism, Single NucleotideReinfectionSputumTreatment FailureTuberculosisWhole Genome Sequencingantibiotic resistanceepidemiologygenomicsglobal healthinfectious diseasemicrobial evolutionmicrobiologyMycobacterium tuberculosissequencing

Identifiers

PMID33522489
PMCPMC7884073
OpenAlexW3128373761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.