Evidence map›Paper›PMID 33522481›Full record

ArticleeLife2021

Robustness of the microtubule network self-organization in epithelia.

Aleksandra Z Płochocka, Miguel Ramirez Moreno, Alexander M Davie, Natalia A Bulgakova, Lyubov Chumakova

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  3. Microorganisms · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Aleksandra Z PłochockaCenter for Computational Biology, Flatiron Institute, New York, United States.ORCID 0000-0003-4739-1320
Miguel Ramirez MorenoDepartment of Biomedical Science, The University of Sheffield, Sheffield, United Kingdom.ORCID 0000-0003-1559-8976
Alexander M DavieMaxwell Institute for Mathematical Sciences, School of Mathematics, Edinburgh University, Edinburgh, United Kingdom.
Natalia A Bulgakova *Department of Biomedical Science, The University of Sheffield, Sheffield, United Kingdom.ORCID 0000-0002-3780-8164
Lyubov Chumakova *Maxwell Institute for Mathematical Sciences, School of Mathematics, Edinburgh University, Edinburgh, United Kingdom.ORCID 0000-0003-2551-3905
Maxwell Institute for Mathematical Sciences · GBUniversity of Sheffield · GBFlatiron Health (United States) · US

Funding

Biotechnology and Biological Sciences Research Council BB/P007503/1
6 · The paper itself

Abstract

Robustness of biological systems is crucial for their survival, however, for many systems its origin is an open question. Here, we analyze one subcellular level system, the microtubule cytoskeleton. Microtubules self-organize into a network, along which cellular components are delivered to their biologically relevant locations. While the dynamics of individual microtubules is sensitive to the organism's environment and genetics, a similar sensitivity of the overall network would result in pathologies. Our large-scale stochastic simulations show that the self-organization of microtubule networks is robust in a wide parameter range in individual cells. We confirm this robustness

Indexed as

CytoskeletonMicrotubulesAnimalsComputer SimulationDrosophila melanogasterEpithelial CellsModels, Theoreticalcell biologycytoskeletonDrosophilamicrotubuleself-organization

Identifiers

PMID33522481
PMCPMC7920549
OpenAlexW3127465674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.