Evidence map›Paper›PMID 33522413›Full record

ArticleAmerican journal of physiology. Renal physiology2021

Epigenetic regulation of arginine vasopressin receptor 2 expression by PAX2 and Pax transcription interacting protein.

Saji Abraham, Raghavendra Paknikar, Samina Bhumbra, Danny Luan, Madhusudan Venkatareddy, Christopher O'Connor, Markus Bitzer, Robert A Fenton, Toby Hurd, Puneet Garg and 1 more

Open access · goldAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Transcriptional regulatory factors of the Aqp2 gene.Kidney research and clinical practice · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Saji AbrahamNephrology Division of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan.
Raghavendra PaknikarNephrology Division of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan.
Samina BhumbraNephrology Division of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan.
Danny LuanNephrology Division of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan.
Madhusudan VenkatareddyNephrology Division of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan.
Christopher O'ConnorNephrology Division of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan.
Markus BitzerNephrology Division of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan.
Robert A FentonDepartment of Biomedicine and Health, Aarhus University, Aarhus, Denmark.
Toby HurdNephrology Division of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan.
Puneet GargNephrology Division of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan.
Sanjeevkumar R PatelNephrology Division of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan.ORCID 0000-0002-6715-6064
Michigan Medicine · USUnited States Department of Veterans Affairs · USAarhus University · DK

Funding

Training in STIs and infections of global health significanceT32AI007637 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI WOOLS-KALOUSTIAN, KARA KAY · 2001 to 2020
$3.4M
Shp2 a Non-Receptor Tyrosine Phosphatase Regulates Nephrin Phosphorylation and PoR01DK097027 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARG, PUNEET · 2014 to 2018
$1.7M
Mechanism of Gene Repression in the KidneyR01DK082409 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PATEL, SANJEEVKUMAR R · 2009 to 2013
$1.5M
NIAID NIH HHS T32 AI007637NIDDK NIH HHS R01 DK082409NIDDK NIH HHS R01 DK097027
6 · The paper itself

Abstract

Renal arginine vasopressin receptor 2 (AVPR2) plays a crucial role in osmoregulation. Engagement of ligand with AVPR2 results in aquaporin 2 movement to the apical membrane and water reabsorption from the urinary filtrate. Despite this essential role, little is known about transcriptional regulation of

Indexed as

AnimalsCarrier ProteinsCell NucleusEpigenesis, GeneticGene Expression RegulationNuclear ProteinsPAX2 Transcription FactorReceptors, VasopressinCarrier ProteinsNuclear ProteinsPAX2 Transcription FactorReceptors, Vasopressinarginine vasopressin receptor 2epigeneticsPAX2Pax transcription interacting proteintranscription regulation

Identifiers

PMID33522413
PMCPMC7988803
OpenAlexW3126406440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.