Evidence map›Paper›PMID 33522393›Full record

ArticleCell cycle (Georgetown, Tex.)2021

Exosomal miR-487a derived from m2 macrophage promotes the progression of gastric cancer.

Xuefeng Yang, Shuang Cai, Yue Shu, Xun Deng, Yuanwei Zhang, Nian He, Lei Wan, Xu Chen, Yan Qu, Shouyang Yu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xuefeng YangDepartment of Gastrointestinal Surgery, Affiliated Hospital of Zunyi Medical University , Zunyi, China.
Shuang CaiDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Zunyi Medical University , Zunyi, China.
Yue ShuKey Laboratory of Brain Science, Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical University , Zunyi, China.
Xun DengDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Zunyi Medical University , Zunyi, China.
Yuanwei ZhangDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Zunyi Medical University , Zunyi, China.
Nian HeDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Zunyi Medical University , Zunyi, China.
Lei WanDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Zunyi Medical University , Zunyi, China.
Xu ChenDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Zunyi Medical University , Zunyi, China.
Yan QuDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Zunyi Medical University , Zunyi, China.
Shouyang YuKey Laboratory of Brain Science, Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical University , Zunyi, China.ORCID 0000-0003-3198-4025
Zunyi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-associated macrophages contribute to cell growth, development, and metastasis in various cancers. However, the underlying mechanisms of M2 macrophage that modulate the progression of gastric cancer (GC) remain largely unknown. In this study, we detected the ratio of macrophages in GC tissues and found that the proportion of M2 macrophages was increased in GC tissues. We then co-cultured GC cells with M1 and M2 macrophages, respectively, and then assessed cell proliferation and tumorigenicity of GC cells by MTT and colony formation assay. The results indicated that M2 macrophages promoted the proliferation of GC cells, but M1 not. Besides, GW4869, an exosomes inhibitor, reduced the effects induced by M2 macrophage. Then, we isolated and identified exosomes derived from M1 and M2 macrophage, and confirmed that the exosomes could be taken up by GC cells. We demonstrated that M2 macrophage-exosomes could induce the proliferation and tumorigenesis

Indexed as

Disease ProgressionAnimalsCell ProliferationCoculture TechniquesExosomesHumansMacrophagesMaleMiceMice, Inbred BALB CMice, NudeMicroRNAsStomach NeoplasmsMicroRNAsMIRN487 microRNA, humanexosomegastric cancerM2 macrophagemicroRNAproliferationtumorigenesis

Identifiers

PMID33522393
PMCPMC7894454
OpenAlexW3128608286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.