Evidence map›Paper›PMID 33522315›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Design, synthesis and biological evaluation of 1-Aryl-5-(4-arylpiperazine-1-carbonyl)-1

Chao Wang, Yuelin Li, Zi Liu, Zeyu Wang, Zihan Liu, Shuai Man, Yujing Zhang, Kai Bao, Yingliang Wu, Qi Guan and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Triple targeting of mutant EGFRJournal of enzyme inhibition and medicinal chemistry · 2023
    Article
  5. Article
  6. Review
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Chao WangKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.ORCID https://orcid.org/0000-0002-1551-3592
Yuelin LiKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Zi LiuDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China.
Zeyu WangWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China.
Zihan LiuKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Shuai ManDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China.
Yujing ZhangKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Kai BaoWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China.
Yingliang WuDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China.
Qi GuanKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.ORCID https://orcid.org/0000-0002-5003-8723
Daiying ZuoDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China.
Weige ZhangKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Shenyang Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of 1-aryl-5-(4-arylpiperazine-1-carbonyl)-1

Indexed as

Drug DesignAntineoplastic AgentsCell CycleCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMicrotubulesMicrowavesModels, MolecularMolecular StructurePolymerizationStructure-Activity RelationshipTetrazolesTubulinTubulin ModulatorsAntineoplastic AgentsTetrazolesTubulinTubulin Modulatorsantiproliferative activitymicrotubule destabilizermicrowavemolecular dockingTetrazole

Identifiers

PMID33522315
PMCPMC8759721
OpenAlexW3126686850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.