Evidence map›Paper›PMID 33522072›Full record

ArticleThoracic cancer2021

Prognostic significance of genetic variants in GLUT1 in stage III non-small cell lung cancer treated with radiotherapy.

Min Kyu Kang, Shin Yup Lee, Jin Eun Choi, Sun Ah Baek, Sook Kyung Do, Jeong Eun Lee, Jongmoo Park, Seung Soo Yoo, Sunha Choi, Kyung Min Shin and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thoracic cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Min Kyu KangDepartment of Radiation Oncology, School of Medicine, Kyungpook National University, Daegu, South Korea.ORCID 0000-0002-7962-7054
Shin Yup LeeDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.ORCID 0000-0002-2121-7335
Jin Eun ChoiDepartment of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Sun Ah BaekCell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea.
Sook Kyung DoDepartment of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Jeong Eun LeeDepartment of Radiation Oncology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Jongmoo ParkDepartment of Radiation Oncology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Seung Soo YooDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Sunha ChoiDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Kyung Min ShinDepartment of Radiology, School of Medicine, Kyungpook National University, Daegu, South Korea.ORCID 0000-0003-4109-0228
Ji Yun JeongDepartment of Pathology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Jae Yong ParkDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.ORCID 0000-0001-7993-4495
Kyungpook National University · KR

Funding

Kyungpook National University Hospital
6 · The paper itself

Abstract

backgroundTo examine the impact of polymorphisms of glucose transporter 1 (GLUT1) gene on the prognosis of patients with stage III non-small cell lung cancer (NSCLC) who received radiotherapy.

methodsFive single nucleotide polymorphisms (SNPs) (rs4658C>G, rs1385129G>A, rs3820589A>T, rs3806401A>C and rs3806400C>T) in GLUT1 gene were evaluated in 90 patients with pathologically confirmed stage III NSCLC. A total of 21 patients were treated with radiotherapy alone, 25 with sequential chemoradiotherapy, and 44 with concurrent chemoradiotherapy. The association of the genetic variations of five SNPs with overall survival (OS) and progression-free survival (PFS) was analyzed.

resultsTwo SNPs (rs1385129 and rs3806401) were significant risk factors for OS. Three SNPs (rs1385129, rs3820589 and rs3806401) were in linkage disequilibrium. In Cox proportional hazard models, GAA haplotype was a good prognostic factor for OS (hazard ratio [HR] = 0.57, 95% confidence interval [CI]: 0.39-0.81, p = 0.002) and PFS (HR = 0.68, 95% CI: 0.47-0.99, p = 0.043), compared to variant haplotypes. The GAA/GAA diplotype was observed in 46.7% of patients; these patients showed significantly better OS (HR = 0.38, 95% CI: 0.22-0.65, p < 0.001) and PFS (HR = 0.51, 95% CI: 0.31-0.85, p = 0.009) compared to those with other diplotypes.

conclusionsThese results suggest that polymorphisms of GLUT1 gene could be used as a prognostic marker for patients with stage III NSCLC treated with radiotherapy.

Indexed as

AgedAged, 80 and overCarcinoma, Non-Small-Cell LungFemaleGenetic VariationGlucose Transporter Type 1HumansLung NeoplasmsMaleMiddle AgedNeoplasm StagingPolymorphism, Single NucleotidePrognosisGlucose Transporter Type 1SLC2A1 protein, humanGLUT1non-small cell lung cancerpolymorphismsradiotherapy

Identifiers

PMID33522072
PMCPMC7952810
OpenAlexW3128761292

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.