ReviewDevelopmental dynamics : an official publication of the American Association of Anatomists2021
Limb positioning and initiation: An evolutionary context of pattern and formation.
Review in Developmental dynamics : an official publication of the American Association of Anatomists, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Transient cell states encode positional information to direct asymmetric growth.bioRxiv : the preprint server for biology · 2026Article
- Metamorphosis and lncRNAs: A Close Relationship.Genesis (New York, N.Y. : 2000) · 2026Review
- Unraveling the Clinical and Genetic Landscape of Talipes Equinovarus (Clubfoot).Molecular syndromology · 2026Review
- Article
- A review of genetic variation underlying chicken phenotypic diversity.Poultry science · 2025Review
- Adaptive evolution ofZoological research · 2025Article
- Thalidomide-induced limb malformations: an update and reevaluation.Archives of toxicology · 2025Review
- Functional evidence supports the potential role of Tbx4-HLEA in the hindlimb degeneration of cetaceans.EvoDevo · 2025Article
- Protein signaling and morphological development of the tail fluke in the embryonic beluga whale (Delphinapterus leucas).Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Sall genes regulate hindlimb initiation in mouse embryos.Genetics · 2024Article
- MSX1Stem cell reports · 2024Article
- Protein-protein interaction network module changes associated with the vertebrate fin-to-limb transition.Scientific reports · 2023Article
- Constructing the pharyngula: Connecting the primary axial tissues of the head with the posterior axial tissues of the tail.Cells & development · 2023Review
- Developmental regulation of conserved non-coding element evolution provides insights into limb loss in squamates.Science China. Life sciences · 2023Article
- A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2.Nature communications · 2023Article
- The role of timing in the development and evolution of the limb.Frontiers in cell and developmental biology · 2023Review
- Mechanical Regulation of Limb Bud Formation.Cells · 2022Review
- Recombinant Limb Assay asFrontiers in cell and developmental biology · 2022Article
- Wnt Signaling Coordinates the Expression of Limb Patterning Genes During Axolotl Forelimb Development and Regeneration.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Before limbs or fins, can be patterned and grow they must be initiated. Initiation of the limb first involves designating a portion of lateral plate mesoderm along the flank as the site of the future limb. Following specification, a myriad of cellular and molecular events interact to generate a bud that will grow and form the limb. The past three decades has provided a wealth of understanding on how those events generate the limb bud and how variations in them result in different limb forms. Comparatively, much less attention has been given to the earliest steps of limb formation and what impacts altering the position and initiation of the limb have had on evolution. Here, we first review the processes and pathways involved in these two phases of limb initiation, as determined from amniote model systems. We then broaden our scope to examine how variation in the limb initiation module has contributed to biological diversity in amniotes. Finally, we review what is known about limb initiation in fish and amphibians, and consider what mechanisms are conserved across vertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.