ArticleScience China. Life sciences2021
The new chimeric chiron genes evolved essential roles in zebrafish embryonic development by regulating NAD
Article in Science China. Life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 9 citations in OpenAlex.
- Functional innovation through new genes as a general evolutionary process.Nature genetics · 2025Review
- Cofea: correlation-based feature selection for single-cell chromatin accessibility data.Briefings in bioinformatics · 2023Article
- Monsoon boosted radiation of the endemic East Asian carps.Science China. Life sciences · 2023Article
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Authors and funding
4 authors at 3 institutions in 1 country.
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Abstract
The origination of new genes is important for generating genetic novelties for adaptive evolution and biological diversity. However, their potential roles in embryonic development, evolutionary processes into ancient networks, and contributions to adaptive evolution remain poorly investigated. Here, we identified a novel chimeric gene family, the chiron family, and explored its genetic basis and functional evolution underlying the adaptive evolution of Danioninae fishes. The ancestral chiron gene originated through retroposition of nampt in Danioninae 48-54 million years ago (Mya) and expanded into five duplicates (chiron1-5) in zebrafish 1-4 Mya. The chiron genes (chirons) likely originated in embryonic development and gradually extended their expression in the testis. Functional experiments showed that chirons were essential for zebrafish embryo development. By integrating into the NAD
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