ArticleBrain : a journal of neurology2021
Cortical connectivity of the nucleus basalis of Meynert in Parkinson's disease and Lewy body dementias.
Article in Brain : a journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration.Nature communications · 2022Trial
- Frequency- and Network-Specific Changes in Functional Connectivity Reflect Pathophysiological Mechanisms across Parkinson's Disease Stages.Annals of neurology · 2026Article
- Deep brain stimulation of the nucleus basalis of Meynert in neurodegenerative diseases with cognitive impairment: An update on evidence and mechanisms.Neural regeneration research · 2026Article
- Cognitive Impairment in Temporal Lobe Epilepsy: Alterations in the Basal Forebrain Cholinergic System.Brain and behavior · 2025Article
- Disruption of low-frequency narrowband EEG microstate networks in Parkinson's disease with mild cognitive impairment.Journal of neuroengineering and rehabilitation · 2025Article
- Interaction of motor behaviour, cortical oscillations and deep brain stimulation in Parkinson's disease.Brain : a journal of neurology · 2025Article
- Involvement of the basal forebrain and hippocampus in memory deficits in Parkinson's disease.Parkinsonism & related disorders · 2024Article
- The role of the nucleus basalis of Meynert in neuromodulation therapy: a systematic review from the perspective of neural network oscillations.Frontiers in aging neuroscience · 2024Review
- REM Sleep Behavior Disorder and Cognitive Functions in Parkinson's Patients: A Systematic Review.Journal of clinical medicine · 2023Review
- Deep Learning Segmentation of the Nucleus Basalis of Meynert on 3T MRI.AJNR. American journal of neuroradiology · 2023Article
- Cholinergic basal forebrain atrophy in Parkinson's disease with freezing of gait.Annals of clinical and translational neurology · 2023Article
- Cortical connectivity of cholinergic basal forebrain in Parkinson's disease with mild cognitive impairment.Quantitative imaging in medicine and surgery · 2023Article
- Deep brain stimulation of the nucleus basalis of Meynert modulates hippocampal-frontoparietal networks in patients with advanced Alzheimer's disease.Translational neurodegeneration · 2022Article
- Imaging the Limbic System in Parkinson's Disease-A Review of Limbic Pathology and Clinical Symptoms.Brain sciences · 2022Review
- Association of Nucleus Basalis of Meynert Functional Connectivity and Cognition in Idiopathic Rapid-Eye-Movement Sleep Behavior Disorder.Journal of clinical neurology (Seoul, Korea) · 2022Article
- Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex.Nature communications · 2022Article
- Event-related oscillations differentiate between cognitive, motor and visual impairments.Journal of neurology · 2022Article
- Cholinergic system changes in Parkinson's disease: emerging therapeutic approaches.The Lancet. Neurology · 2022Review
- Basal Forebrain Impairment: Understanding the Mnemonic Function of the Septal Region Translates in Therapeutic Advances.Frontiers in neural circuits · 2022Review
- Metric magnetic resonance imaging analysis reveals pronounced substantia-innominata atrophy in dementia with Lewy bodies with a psychiatric onset.Frontiers in aging neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are related conditions that are associated with cholinergic system dysfunction. Dysfunction of the nucleus basalis of Meynert (NBM), a basal forebrain structure that provides the dominant source of cortical cholinergic innervation, has been implicated in the pathogenesis of both PDD and DLB. Here we leverage the temporal resolution of magnetoencephalography with the spatial resolution of MRI tractography to explore the intersection of functional and structural connectivity of the NBM in a unique cohort of PDD and DLB patients undergoing deep brain stimulation of this structure. We observe that NBM-cortical structural and functional connectivity correlate within spatially and spectrally segregated networks including: (i) a beta band network to supplementary motor area, where activity in this region was found to drive activity in the NBM; (ii) a delta/theta band network to medial temporal lobe structures encompassing the parahippocampal gyrus; and (iii) a delta/theta band network to visual areas including lingual gyrus. These findings reveal functional networks of the NBM that are likely to subserve important roles in motor control, memory and visual function, respectively. Furthermore, they motivate future studies aimed at disentangling network contribution to disease phenotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.