Evidence map›Paper›PMID 33521650›Full record

ArticleKidney3602020

Assessing Polycystic Kidney Disease in Rodents: Comparison of Robotic 3D Ultrasound and Magnetic Resonance Imaging.

Nathan J Beaumont, Heather L Holmes, Adriana V Gregory, Marie E Edwards, Juan D Rojas, Ryan C Gessner, Paul A Dayton, Timothy L Kline, Michael F Romero, Tomasz J Czernuszewicz

Open access · diamondAbstract read
In one paragraph

Article in Kidney360, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Nathan J BeaumontSonoVol, Inc., Durham, North Carolina.
Heather L HolmesDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Adriana V GregoryNephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Marie E EdwardsRadiology, Mayo Clinic, Rochester, Minnesota.
Juan D RojasSonoVol, Inc., Durham, North Carolina.
Ryan C GessnerSonoVol, Inc., Durham, North Carolina.
Paul A DaytonJoint Department of Biomedical Engineering, The University of North Carolina and North Carolina State University, Chapel Hill, North Carolina.
Timothy L KlineNephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Michael F RomeroDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Tomasz J CzernuszewiczSonoVol, Inc., Durham, North Carolina.ORCID 0000-0002-5493-4058
Mayo Clinic · USSonoVol (United States) · USNorth Carolina State University · US

Funding

Pilot and FeasibilityP30DK090728 · NIDDK · MAYO CLINIC ROCHESTER · PI TORRES, VICENTE E · 2010 to 2019
$11.8M
A new robotic AI imaging platform for improved kidney disease research and drug discoveryR43DK126607 · NIDDK · SONOVOL, INC. · PI CZERNUSZEWICZ, TOMASZ JOSEPH · 2020 to 2020
$300k
NIDDK NIH HHS R43 DK126607
6 · The paper itself

Abstract

Polycystic kidney disease (PKD) is an inherited disorder characterized by renal cyst formation and enlargement of the kidney. PKD severity can be staged noninvasively by measuring total kidney volume (TKV), a promising biomarker that has recently received regulatory qualification. In preclinical mouse models, where the disease is studied and potential therapeutics are evaluated, the most popular noninvasive method of measuring TKV is magnetic resonance imaging (MRI). Although MRI provides excellent 3D resolution and contrast, these systems are expensive to operate, have long acquisition times, and, consequently, are not heavily used in preclinical PKD research. In this study, a new imaging instrument, based on robotic ultrasound (US), was evaluated as a complementary approach for assessing PKD in rodent models. The objective was to determine the extent to which TKV measurements on the robotic US scanner correlated with both

Indexed as

Polycystic Kidney DiseasesRobotic Surgical ProceduresAnimalsCross-Sectional StudiesMagnetic Resonance ImagingMiceRodentia

Identifiers

PMID33521650
PMCPMC7842280
OpenAlexW3069981443

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.