Evidence map›Paper›PMID 33521525›Full record

ArticleBMJ nutrition, prevention & health2020

Contrasting prenatal nutrition and environmental exposures in association with birth weight and cognitive function in children at 7 years.

Chris Gennings, Alicja Wolk, Niclas Hakansson, Christian Lindh, Carl-Gustaf Bornehag

Open access · goldAbstract read
In one paragraph

Article in BMJ nutrition, prevention & health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 4 countries.

Chris GenningsDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-6058-5907
Alicja WolkDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Niclas HakanssonInstitute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Christian LindhDivision of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Carl-Gustaf BornehagPublic Health Sciences, Karlstad University, Karlstad, Sweden.
Faculty of Public Health · GBIcahn School of Medicine at Mount Sinai · USKarolinska Institutet · SELund University · SEUppsala University · SE

Funding

The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Manish Arora · 2014 to 2026
$21.3M
Methods for Data Integration and Risk Assessment for Environmental MixturesR01ES028811 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI COULL, BRENT ANDREW, GENNINGS, CHRIS · 2018 to 2021
$1.9M
NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R01 ES028811
6 · The paper itself

Abstract

backgroundGood nutrition is essential for individual health, a notion that is particularly true during pregnancy. We have used a nutrition index that measures the adequacy of one's diet relative to the unique nutritional needs of individuals due to, for example, their activity level, dietary restrictions, lifestyle and body size. The use of this personalised metric of dietary nutritiousness in the analysis of prenatal environmental exposures and developmental outcomes permits testing for potential mitigating effects of good nutrition. We also provide an analysis strategy for investigating the balance in beneficial food sources which are also the source of environmental toxicants.

methodsA holistic measure of nutrition,

resultsUsing prenatal Food Frequency Questionnaire data to construct an individual's MNI, the index was significantly and positively associated with important metabolic outcome (as measured by birth weight) and cognitive function at age 7 years (as measured by WISC IQ) in children when adjusted for covariates and prenatal concentrations of an EDC. In a stratified analysis of 'low' and 'high' fish consumption, a potential source of perfluoro-octanesulfonic acid (PFOS), the association between PFOS and birth weight was diminished in the high consumption group compared with the low consumption group.

conclusionsThus, MNI is evidently a metric of the general nutritiousness of daily diets and is useful in environmental health studies in representing the impact of good nutrition, even during pregnancy.

Indexed as

cognitive performancenutrition assessment

Identifiers

PMID33521525
PMCPMC7841844
OpenAlexW3044505012

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.