Evidence map›Paper›PMID 33521522›Full record

ArticleBMJ nutrition, prevention & health2020

Association between plant-based diets and blood pressure in the INTERMAP study.

Ghadeer Aljuraiban, Queenie Chan, Rachel Gibson, Jeremiah Stamler, Martha L Daviglus, Alan R Dyer, Katsuyuki Miura, Yangfeng Wu, Hirotsugu Ueshima, Liancheng Zhao and 4 more

Registry-linked trialAbstract read
In one paragraph

Article in BMJ nutrition, prevention & health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005271 (INTERMAP), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00005271 completednot on this map

INTERMAP: International Population Study on Macronutrients and BP

TypeobservationalSponsorNorthwestern UniversityRan1995 to 2015Enrolled4,680ConditionsCardiovascular Diseases, Heart Diseases, Hypertension
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
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  11. Diet to Stop Hypertension: Should Fats be Included?Current hypertension reports · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ghadeer AljuraibanDepartment of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.ORCID 0000-0002-4866-5461
Queenie ChanDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Rachel GibsonDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Jeremiah StamlerDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Martha L DaviglusCollege of Medicine, Institute for Minority Health Research, University of Illinois at Chicago, Chicago, Illinois, USA.
Alan R DyerDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Katsuyuki MiuraDepartment of Public Health, Shiga University of Medical Science, Otsu, Shiga, Japan.
Yangfeng WuClinical Research Institute and School of Public Health, Peking University, Beijing, Beijing, China.
Hirotsugu UeshimaDepartment of Public Health, Shiga University of Medical Science, Otsu, Shiga, Japan.
Liancheng ZhaoDivision of Prevention and Community Health, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Linda Van HornDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Paul ElliottDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Linda M Oude GriepDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
INTERMAP Research Group

Funding

INTL POPULATION STUDY ON MACRONUTRIENTS AND BP INTERMAPR01HL050490 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DAVIGLUS, MARTHA L, ELLIOTT, PAUL · 1995 to 2013
$7.3M
Metabolomics-Measured Urinary Metabolites, Diet & BP, 17 Population Samples: INTER01HL084228 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DAVIGLUS, MARTHA L, ELLIOTT, PAUL · 2007 to 2014
$4.2M
Metabolic Pathways Underlying the Contrasting Sodium-BP and DASH/OmniHeart-BP RelationshipsR01HL135486 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DAVIGLUS, MARTHA L, ELLIOTT, PAUL · 2017 to 2020
$2.6M
AMINO ACIDS IN URINE, DIET &BP: INT'L POPULATION STUDYR01HL065461 · NHLBI · NORTHWESTERN UNIVERSITY · PI DAVIGLUS, MARTHA L · 2000 to 2003
$1.0M
Medical Research Council MR/S019669/1NHLBI NIH HHS R01 HL050490NHLBI NIH HHS R01 HL065461NHLBI NIH HHS R01 HL084228NHLBI NIH HHS R01 HL135486
6 · The paper itself

Abstract

backgroundPlant-based diets are associated with a lower risk of cardiovascular diseases; however, little is known how the healthiness of the diet may be associated with blood pressure (BP). We aimed to modify three plant -based diet indices: overall plant-based diet index (PDI), healthy PDI (hPDI), and unhealthy PDI (uPDI) according to country-specific dietary guidelines to enable use across populations with diverse dietary patterns - and assessed their associations with BP.

designWe used cross-sectional data including 4,680 men and women ages 40-59y in Japan, China, the United Kingdom, and the United States from the INTERnational study on MAcro/micronutrients and blood Pressure (INTERMAP). During four visits, eight BP measurements, and four 24-h dietary recalls were collected. Multivariable regression coefficients were estimated, pooled, weighted, and adjusted extensively for lifestyle/dietary confounders.

resultsModified PDI was not associated with BP. Consumption of hPDI higher by 1SD was inversely associated with systolic (-0.82 mm Hg;95% CI:-1.32,-0.49) and diastolic BP (-0.49 mm Hg; 95% CI:-0.91, -0.28). In contrast, consumption of an uPDI was directly associated with systolic (0.77 mm Hg;95% CI:0.30,1.20). Significant associations between hPDI with BP were attenuated with separate adjustment for vegetables and whole grains; associations between uPDI and BP were attenuated after adjustment for refined grains, sugar-sweetened beverages, and meat.

conclusionAn hPDI is associated with lower BP while a uPDI is adversely related to BP. Plant-based diets rich in vegetables and whole grains and limited in refined grains, sugar-sweetened beverages, and total meat may contribute to these associations. In addition to current guidelines, the nutritional quality of consumed plant foods is as important as limiting animal-based components. TRIAL REGISTRATION NUMBER: The observational INTERMAP study was registered at www.clinicaltrials.gov as NCT00005271.

Indexed as

blood pressure loweringdietary patterns

Identifiers

PMID33521522
PMCPMC7841826

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.