Evidence map›Paper›PMID 33521322›Full record

ArticleTranslational medicine communications2021

Statins in patients with COVID-19: a retrospective cohort study in Iranian COVID-19 patients.

Payam Peymani, Tania Dehesh, Farnaz Aligolighasemabadi, Mohammadamin Sadeghdoust, Katarzyna Kotfis, Mazaher Ahmadi, Parvaneh Mehrbod, Pooya Iranpour, Sanaz Dastghaib, Ahmad Nasimian and 13 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational medicine communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. The Association Between the Use of Statins and Clinical Outcomes in Patients with COVID-19: A Systematic Review and Meta-analysis.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2022
    Pooled it
  2. Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 14 institutions in 5 countries.

Payam Peymani *Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Tania Dehesh *Department of Biostatistics and Epidemiology, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran.
Farnaz AligolighasemabadiDepartment of Internal Medicine, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran.
Mohammadamin SadeghdoustDepartment of Internal Medicine, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran.
Katarzyna KotfisDepartment of Anesthesiology, Intensive Therapy and Acute Intoxications, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
Mazaher AhmadiDepartment of Analytical Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
Parvaneh MehrbodInfluenza and Respiratory Viruses Department, Pasteur Institute of IRAN, Tehran, Iran.
Pooya IranpourMedical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Sanaz DastghaibShiraz Endocrine and Metabolism Research Center, Namazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Ahmad NasimianDepartment of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Amir RavandiSection of Cardiology, St. Boniface Hospital, University of Manitoba, Winnipeg, MB Canada.
Biniam KidaneDepartment of Surgery, University of Manitoba, Winnipeg, Manitoba Canada.
Naseer AhmedDepartment of Radiology, University of Manitoba, Winnipeg, Manitoba Canada.
Pawan SharmaCenter for Translational Medicine, Thomas Jefferson University, Philadelphia, PA USA.
Shahla ShojaeiCollege of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba Canada.
Kamran Bagheri LankaraniHealth Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Andrzej MadejFaculty of Medicine, Katowice School of Technology, 40-555 Katowice, Poland.
Nima RezaeiResearch Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Tayyebeh MadrakianDepartment of Analytical Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
Marek J LosBiotechnology Center, Silesian University of Technology, 44-100 Gliwice, Poland.
Hagar Ibrahim LaboutaCollege of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba Canada.
Pooneh Mokarram *Autophagy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Saeid Ghavami *Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID 0000-0001-5948-508X
Shiraz University of Medical Sciences · IRUniversity of Manitoba · CABu-Ali Sina University · IRIslamic Azad University, Mashhad · IRAkademia Śląska · PLCancerCare Manitoba · CAKerman University of Medical Sciences · IRPasteur Institute of Iran · IRPomeranian Medical University · PLSilesian University of Technology · PLSt. Boniface Hospital · CATarbiat Modares University · IRThomas Jefferson University · USUniversal Scientific Education and Research Network · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has profoundly affected the lives of millions of people. To date, there is no approved vaccine or specific drug to prevent or treat COVID-19, while the infection is globally spreading at an alarming rate. Because the development of effective vaccines or novel drugs could take several months (if not years), repurposing existing drugs is considered a more efficient strategy that could save lives now. Statins constitute a class of lipid-lowering drugs with proven safety profiles and various known beneficial pleiotropic effects. Our previous investigations showed that statins have antiviral effects and are involved in the process of wound healing in the lung. This triggered us to evaluate if statin use reduces mortality in COVID-19 patients.

resultsAfter initial recruitment of 459 patients with COVID-19 (Shiraz province, Iran) and careful consideration of the exclusion criteria, a total of 150 patients, of which 75 received statins, were included in our retrospective study. Cox proportional-hazards regression models were used to estimate the association between statin use and rate of death. After propensity score matching, we found that statin use appeared to be associated with a lower risk of morbidity [HR = 0.85, 95% CI = (0.02, 3.93),

conclusionsAlthough we could not demonstrate a significant association between statin use and a reduction in mortality in patients with COVID19, we do feel that our results are promising and of clinical relevance and warrant the need for prospective randomized controlled trials and extensive retrospective studies to further evaluate and validate the potential beneficial effects of statin treatment on clinical symptoms and mortality rates associated with COVID-19.

Indexed as

COVID-19Pleiotropic effectsRepurposingRetrospective studySARS-CoV-2Statins

Identifiers

PMID33521322
PMCPMC7829327
OpenAlexW3112703544

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.