ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
A quadratic function of activation in individuals at risk of Alzheimer's disease.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- EEG Microstate Alterations in Eyes-Open and Eyes-Closed Resting States Across the Alzheimer's Disease Continuum.Journal of clinical medicine · 2026Article
- Simultaneous PET/fMRI distinguishes the separate and synergistic effects of T2DM and MCI on cerebral glucose metabolism and fALFF.Scientific reports · 2026Article
- Dysfunction of the episodic memory network in the Alzheimer's disease cascade.Nature communications · 2026Article
- Predicting the degree of trait emotional empathy from cortical features using surface-based morphometry.Scientific reports · 2026Article
- Distinct patterns of spontaneous brain activity in mild cognitive impairment patients stratified by cerebrospinal fluid biomarkers.Frontiers in aging neuroscience · 2026Article
- Precuneus Activity during Retrieval Is Positively Associated with Amyloid Burden in Cognitively Normal OlderThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Predicting cognitive change using functional, structural, and neuropsychological predictors.Brain communications · 2025Article
- Therapeutic and preventive strategies based on the maladaptive plasticity hypothesis for Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
- Biophysical models applied to dementia patients reveal links between geographical origin, gender, disease duration, and loss of neural inhibition.Alzheimer's research & therapy · 2024Article
- Dynamic multilayer functional connectivity detects preclinical and clinical Alzheimer's disease.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Self-supervised multimodal learning for group inferences from MRI data: Discovering disorder-relevant brain regions and multimodal links.NeuroImage · 2024Article
- Cerebral hyperactivation across the Alzheimer's disease pathological cascade.Brain communications · 2024Review
- Multivariate mediation analysis with voxel-based morphometry revealed the neurodegeneration pathways from genetic variants to Alzheimer's Disease.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2024Article
- Predicting cognitive decline in a low-dimensional representation of brain morphology.Scientific reports · 2023Article
- Neural network process simulations support a distributed memory system and aid design of a novel computer adaptive digital memory test for preclinical and prodromal Alzheimer's disease.Neuropsychology · 2023Article
- Nonlinear changes in delayed functional network topology in Alzheimer's disease: relationship with amyloid and tau pathology.Alzheimer's research & therapy · 2023Article
- Investigating Compensatory Brain Activity in Older Adults with Subjective Cognitive Decline.Journal of Alzheimer's disease : JAD · 2023Article
- Antisaccadic eye movements in middle-aged individuals with a family history of Alzheimer's disease.Frontiers in human neuroscience · 2023Article
- Novelty-Related fMRI Responses of Precuneus and Medial Temporal Regions in Individuals at Risk for Alzheimer Disease.Neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBrain activation is hypothesized to form an inverse U-shape in prodromal Alzheimer's disease (AD), with hyperactivation in the early phase, followed by hypoactivation.
methodsUsing task-related functional magnetic resonance imaging (fMRI), we tested the inverse U-shape hypothesis with polynomial regressions and between-group comparisons in individuals with subjective cognitive decline plus (SCD
resultsA quadratic function modeled the relationship between proxies of disease severity (neurodegeneration, memory performance) and left superior parietal activation. Linear negative functions modeled the relationship between neurodegeneration and left hippocampal/right inferior temporal activation. Group comparison indicated presence of hyperactivation in SCD DISCUSSION: These findings support the presence of an inverse U-shape model of activation and suggest that hyperactivation might represent a biomarker of the early AD stages.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.