Evidence map›Paper›PMID 33520997›Full record

ReviewFrontiers in cell and developmental biology2020

TET-Mediated Epigenetic Regulation in Immune Cell Development and Disease.

Nikolas James Tsiouplis, David Wesley Bailey, Lilly Felicia Chiou, Fiona Jane Wissink, Ageliki Tsagaratou

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
  2. Article
  3. Intrinsic regulation of intestinal stem cell fate and homeostasis by Tet.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. TET3-overexpressing macrophages promote endometriosis.The Journal of clinical investigation · 2024
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nikolas James TsiouplisUniversity of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC, United States.
David Wesley BaileyUniversity of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC, United States.
Lilly Felicia ChiouUniversity of North Carolina Curriculum in Genetics and Molecular Biology, Chapel Hill, NC, United States.
Fiona Jane WissinkUniversity of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC, United States.
Ageliki TsagaratouUniversity of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC, United States.
University of North Carolina at Chapel Hill · USUNC Lineberger Comprehensive Cancer Center

Funding

NRSA in GeneticsT32GM135128 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel J McKay, JEFF J. SEKELSKY · 2020 to 2026
$5.1M
Epigenetic Regulation of Lineage SpecificationR35GM138289 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TSANGARATOU, AGELIKI · 2020 to 2024
$2.0M
NIGMS NIH HHS R35 GM138289NIGMS NIH HHS T32 GM135128
6 · The paper itself

Abstract

TET proteins oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further oxidation products in DNA. The oxidized methylcytosines (oxi-mCs) facilitate DNA demethylation and are also novel epigenetic marks. TET loss-of-function is strongly associated with cancer;

Indexed as

5hmCcancerepigeneticsimmune cell developmentTET proteins

Identifiers

PMID33520997
PMCPMC7843795
OpenAlexW3120854370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.