ReviewFrontiers in cell and developmental biology2020
Biological Roles and Delivery Strategies for Ions to Promote Osteogenic Induction.
Review in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Plant-based macronutrients and micronutrients in combating osteoporosis: research insights and molecular pathways.RSC advances · 2026Review
- Simultaneous regeneration of skin and bone in full-thickness cranial composite defects.bioRxiv : the preprint server for biology · 2026Article
- Engineering a Bioactive PMMA-Silica Hybrid Scaffold for Enhanced Bone Regeneration.ACS applied bio materials · 2026Article
- Harnessing strontium in regenerative dentistry: progress and perspectives.Frontiers in bioengineering and biotechnology · 2025Review
- Three-dimensional composite aerogel scaffolds based on electrospun poly(lactic acid)/gelatin and silica-strontium oxide short fibers promote bone defect healing.Burns & trauma · 2025Article
- Enhanced functionalities of biomaterials through metal ion surface modification.Frontiers in bioengineering and biotechnology · 2025Review
- Article
- Biochemical Behavior, Influence on Cell DNA Condition, and Microbiological Properties of Wool and Wool-Copper Materials.Materials (Basel, Switzerland) · 2024Article
- Capturing cerium ions via hydrogel microspheres promotes vascularization for bone regeneration.Materials today. Bio · 2024Article
- Article
- Article
- Bioactive elements manipulate bone regeneration.Biomaterials translational · 2023Review
- Article
- Efficacy of soluble lansoprazole-impregnated beta-tricalcium phosphate for bone regeneration.Scientific reports · 2022Article
- Peptides for Coating TiOInternational journal of molecular sciences · 2022Article
- Developing Porous Ortho- and Pyrophosphate-Containing Glass Microspheres; Structural and Cytocompatibility Characterisation.Bioengineering (Basel, Switzerland) · 2022Article
- Cancer Inhibition and In Vivo Osteointegration and Compatibility of Gallium-Doped Bioactive Glasses for Osteosarcoma Applications.ACS applied materials & interfaces · 2022Article
- Zn-Loaded and Calcium Phosphate-Coated Degradable Silica Nanoparticles Can Effectively Promote Osteogenesis in Human Mesenchymal Stem Cells.Nanomaterials (Basel, Switzerland) · 2022Article
- The Effect of CaPolymers · 2022Article
- Modulation of Macrophage Response by Copper and Magnesium Ions in Combination with Low Concentrations of Dexamethasone.Biomedicines · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone is the most studied tissue in the field of tissue regeneration. Even though it has intrinsic capability to regenerate upon injury, several pathologies and injuries could hamper the highly orchestrated bone formation and resorption process. Bone tissue engineering seeks to mimic the extracellular matrix of the tissue and the different biochemical pathways that lead to successful regeneration. For many years, the use of extrinsic factors (i.e., growth factors and drugs) to modulate these biological processes have been the preferred choice in the field. Even though it has been successful in some instances, this approach presents several drawbacks, such as safety-concerns, short release profile and half-time life of the compounds. On the other hand, the use of inorganic ions has attracted significant attention due to their therapeutic effects, stability and lower biological risks. Biomaterials play a key role in such strategies where they serve as a substrate for the incorporation and release of the ions. In this review, the methodologies used to incorporate ions in biomaterials is presented, highlighting the osteogenic properties of such ions and the roles of biomaterials in controlling their release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.