Evidence map›Paper›PMID 33520954›Full record

ArticleFrontiers in bioengineering and biotechnology2020

Laminin-Modified Dental Pulp Extracellular Matrix for Dental Pulp Regeneration.

Jiahui Fu, Jianfeng Chen, Wenjun Li, Xiaomin Yang, Jingyan Yang, Huixin Quan, Haitao Huang, Gang Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jiahui FuDepartment of Stomatology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Jianfeng ChenDepartment of Stomatology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Wenjun LiDepartment of Stomatology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Xiaomin YangDepartment of Stomatology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Jingyan YangDepartment of Stomatology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Huixin QuanDepartment of Stomatology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Haitao HuangDepartment of Stomatology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Gang ChenDepartment of Stomatology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
First Affiliated Hospital of Dalian Medical University · CNDalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Native dental pulp extracellular matrix (DPEM) has proven to be an effective biomaterial for dental pulp regeneration. However, as a significant extracellular matrix glycoprotein, partial laminins were lost during the decellularization process, which were essential for odontoblast differentiation. Thereby, this study investigated the feasibility of LN supplementation to improve the surface of DPEM for odontoblast layer regeneration. The influences of laminin on cell adhesion and odontogenic differentiation were evaluated in vitro. Then, we fabricated laminin-modified DPEM based on the physical coating strategy and observed the location and persistency of laminin coating by immunofluorescent staining. Finally, laminin-modified DPEM combined with treated dentin matrix (TDM) was transplanted in orthotopic jaw bone of beagles (

Indexed as

dental pulpextracellular matrixlamininodontoblastregeneration

Identifiers

PMID33520954
PMCPMC7838611
OpenAlexW3118406670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.