Evidence map›Paper›PMID 33520662›Full record

ArticleJournal of clinical & translational endocrinology2021

Underestimation of risk for large babies in rural and remote Australia: Time to change plasma glucose collection protocols.

Emma L Jamieson, Erica P Spry, Andrew B Kirke, Carly Roxburgh, David N Atkinson, Julia V Marley

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical & translational endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Emma L JamiesonThe University of Western Australia, The Rural Clinical School of Western Australia, Building 3 Edith Cowan University Campus, Robertson Drive, PO Box 412, Bunbury 6230, Australia.
Erica P SpryKimberley Aboriginal Medical Services, 12 Napier Terrace, Broome 6725, Australia.
Andrew B KirkeThe University of Western Australia, The Rural Clinical School of Western Australia, Building 3 Edith Cowan University Campus, Robertson Drive, PO Box 412, Bunbury 6230, Australia.
Carly RoxburghThe University of Western Australia, The Rural Clinical School of Western Australia, 35 Stirling Terrace, Albany 6330, Australia.
David N AtkinsonThe University of Western Australia, The Rural Clinical School of Western Australia, 12 Napier Terrace, PO Box 1377, Broome 6725, Australia.
Julia V MarleyKimberley Aboriginal Medical Services, 12 Napier Terrace, Broome 6725, Australia.
The University of Western Australia · AUEdith Cowan University · AU

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
NCATS NIH HHS UL1 TR002548
6 · The paper itself

Abstract

aimsPreanalytical glycolysis in oral glucose tolerance tests (OGTT) leads to substantial underestimation of gestational diabetes mellitus (GDM) and hence risk for large-for-gestational-age (LGA) babies. This paper quantified the impact of glycolysis on identification of LGA risk in a prospective rural and remote Australian cohort.

methodsFor 495 women, OGTT results from room temperature fluoride-oxalate (FLOX) tubes were algorithmically corrected for estimated glycolysis compared to 1) the Hyperglycaemia and Adverse Pregnancy Outcomes (HAPO) study protocol (FLOX tubes in ice-slurry); and 2) room temperature fluoride-citrate (FC) tubes. GDM was defined by International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria. Unadjusted and corrected OGTT were related to LGA outcome.

resultsCorrection for FC tubes increased GDM incidence from 9.7% to 44.6%. After correction for HAPO protocol, GDM incidence was 27.7% and prediction of LGA risk (RR 1.82, [1.11-2.99]) improved compared to unadjusted rates (RR 1.12, [0.51-2.47]). To provide similar results for FC tube correction (29.3% GDM; RR 1.81, [1.11-2.96]) required + 0.2 mmol/L adjustment of IADPSG criteria.

conclusionsFC tubes present a practical alternative to the HAPO protocol in remote settings but give + 0.2 mmol/L higher glucose readings. Modification of IADPSG criteria would reduce perceived 'overdiagnosis' and improve LGA risk-assessment.

Indexed as

DiagnosticsGestational diabetesGlycolysisIndigenous healthPregnancy outcomesRural and remote health

Identifiers

PMID33520662
PMCPMC7820914
OpenAlexW3120154820

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.