ArticleBioscience of microbiota, food and health2021
Characterisation of gut microbiota of obesity and type 2 diabetes in a rodent model.
Article in Bioscience of microbiota, food and health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Impact of Lutein Supplementation on Liver Health, Oxidative Metabolism, Gut Microbiota, and Growth Performance in High-Fat Diet Fed Mice.Nutrients · 2026Article
- Cafeteria diet exposure, and not weight gain propensity, impacts gut microbiota of rats - a within laboratory meta-analysis.Gut microbes reports · 2026Article
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- Postnatal overfeeding induces gut microbiota disturbances and impairs GPR43/FIAF/LPL pathway in the rat model of PCOS.Journal of physiology and biochemistry · 2025Article
- Anti-Diabetic Potentials of Lactobacillus Strains by Modulating Gut Microbiota Structure and β-Cells Regeneration in the Pancreatic Islets of Alloxan-Induced Diabetic Rats.Probiotics and antimicrobial proteins · 2025Article
- The effect of the administration form of antibiotic therapy on the gut microbiome in patients with infected diabetic foot ulcers - DFIATIM trial.BMC microbiology · 2025Article
- Role of duodenal mucosal resurfacing in controlling diabetes in rats.World journal of diabetes · 2025Article
- Postbiotics and their biotherapeutic potential for chronic disease and their feature perspective: a review.Frontiers in microbiomes · 2025Review
- Interactions between Gut Microbiota and Natural Bioactive Polysaccharides in Metabolic Diseases: Review.Nutrients · 2024Review
- Spatial variations in the microbiota: comparative analysis of microbial composition and predicted functions across different intestinal segments and feces in donkeys.Frontiers in microbiology · 2024Article
- Therapeutic Potentials of Microalgae and Their Bioactive Compounds on Diabetes Mellitus.Marine drugs · 2023Review
- Exploring body weight-influencing gut microbiota by elucidating the association with diet and host gene expression.Scientific reports · 2023Article
- Proanthocyanidins: Impact on Gut Microbiota and Intestinal Action Mechanisms in the Prevention and Treatment of Metabolic Syndrome.International journal of molecular sciences · 2023Review
- Oral Exposure to Polystyrene Microplastics of Mice on a Normal or High-Fat Diet and Intestinal and Metabolic Outcomes.Environmental health perspectives · 2023Article
- Diagnostic potential of energy metabolism-related genes in heart failure with preserved ejection fraction.Frontiers in endocrinology · 2023Article
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Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various studies have suggested that the gut microbiome interacts with the host and may have a significant role in the aetiology of obesity and Type 2 Diabetes (T2D). It was hypothesised that bacterial communities in obesity and T2D differ from control and compromise normal interactions between host and microbiota. Obesity and T2D were developed in rats by feeding a high-fat diet or a high-fat diet plus a single low-dose streptozotocin administration, respectively. The microbiome profiles and their metabolic potentials were established by metagenomic 16S rRNA sequencing and bioinformatics. Taxonomy and predicted metabolism-related genes in obesity and T2D were markedly different from controls and indeed from each other. Diversity was reduced in T2D but not in Obese rats. Factors likely to compromise host intestinal, barrier integrity were found in Obese and T2D rats including predicted, decreased bacterial butyrate production. Capacity to increase energy extraction via ABC-transporters and carbohydrate metabolism were enhanced in Obese and T2D rats. T2D was characterized by increased proinflammatory molecules. While obesity and T2D show distinct differences, results suggest that in both conditions
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.