Evidence map›Paper›PMID 33520428›Full record

ArticleAPL materials2021

Micro-coil probes for magnetic intracortical neural stimulation: Trade-offs in materials and design.

Krishnan Thyagarajan, Rene A Lujan, Qian Wang, JengPing Lu, Sivkheng Kor, Bruce Kakimoto, Norine Chang, Julie A Bert

Open access · goldAbstract read
In one paragraph

Article in APL materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Toward Intrinsically Stretchable OLEDs with High Efficiency.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  2. Microfabrication Technologies for Nanoinvasive and High-Resolution Magnetic Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  3. Nanotechnology Enables Novel Modalities for Neuromodulation.Advanced materials (Deerfield Beach, Fla.) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Krishnan ThyagarajanPalo Alto Research Center (PARC), a Xerox Company, Palo Alto, California 94304, USA.ORCID 0000-0002-5699-4468
Rene A LujanPalo Alto Research Center (PARC), a Xerox Company, Palo Alto, California 94304, USA.
Qian WangPalo Alto Research Center (PARC), a Xerox Company, Palo Alto, California 94304, USA.
JengPing LuPalo Alto Research Center (PARC), a Xerox Company, Palo Alto, California 94304, USA.
Sivkheng KorPalo Alto Research Center (PARC), a Xerox Company, Palo Alto, California 94304, USA.
Bruce KakimotoPalo Alto Research Center (PARC), a Xerox Company, Palo Alto, California 94304, USA.
Norine ChangPalo Alto Research Center (PARC), a Xerox Company, Palo Alto, California 94304, USA.
Julie A BertPalo Alto Research Center (PARC), a Xerox Company, Palo Alto, California 94304, USA.
Palo Alto Research Center · US

Funding

Micro-coil implants for cortical activationU01NS099700 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI FRIED, SHELLEY · 2016 to 2018
$2.9M
NINDS NIH HHS U01 NS099700
6 · The paper itself

Abstract

Neural probes for intracortical neuromodulation in the brain have advanced with the developments in micro- and nanofabrication technologies. Most of these technologies for the intracortical stimulation have relied on the direct electrical stimulation via electrodes or arrays of electrodes. Generating electric fields using time-varying magnetic fields is a more recent neuromodulation technique that has proven to be more specifically effective for the intracortical stimulation. Additionally, current-actuated coils require no conductive contact with tissues and enable precise tailoring of magnetic fields, which are unaffected by the non-magnetic nature of the biological tissue and encapsulation layers. The material and design parameter space for such micro-coil fabrication can be optimized and tailored to deliver the ideal performance depending on the parameters needed for operation. In this work, we review the key requirements for implantable microcoils including the probe structure and material properties and discuss their characteristics and related challenges for the applications in intracortical neuromodulation.

Identifiers

PMID33520428
PMCPMC7808331
OpenAlexW3119935547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.