Evidence map›Paper›PMID 33520427›Full record

ArticleTranslational vision science & technology2021

Efficacy and Safety Outcomes of Cataract Surgery in Survivors of Ebola Virus Disease: 12-Month Results From the PREVAIL VII Study.

Allen O Eghrari, Jessica G Shantha, Robin D Ross, Collin Van Ryn, Ian Crozier, Brent Hayek, Dan Gradin, Ben Roberts, S Grace Prakalapakorn, Fred Amegashie and 14 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational vision science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03309020 (PREVAIL VII), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03309020 nacompletednot on this map

PREVAIL VII: Persistence of Ebola Virus in Ocular Tissues and Outcomes of Cataract Surgery in Survivors of Ebola Virus Disease

TypeinterventionalSponsorNational Eye Institute (NEI)Ran2017 to 2019Enrolled37ConditionsCataractArmsCataract surgery
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 15 institutions in 4 countries.

Allen O EghrariWilmer Eye Institute, Johns Hopkins University Medical Center, Baltimore, MD, USA.
Jessica G ShanthaEmory Eye Center, Emory University School of Medicine, Atlanta, GA, USA.
Robin D RossGlobal Retina Institute, Scottsdale, AZ, USA.
Collin Van RynDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Ian CrozierClinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Brent HayekEmory Eye Center, Emory University School of Medicine, Atlanta, GA, USA.
Dan GradinCasey Eye Institute, Oregon Health and Science University, Portland, OR, USA.
Ben RobertsUniversity of Alabama Birmingham-Callahan Eye Hospital, Birmingham, AL, USA.
S Grace PrakalapakornDepartment of Ophthalmology, Duke University, Durham, NC, USA.
Fred AmegashieMinistry of Health, Monrovia, Liberia.
Kumar NishantL V Prasad Eye Institute, Hyderabad, India.
Gurcharan SinghL V Prasad Eye Institute, Hyderabad, India.
Robert DoloNew Sight Eye Center, Monrovia, Liberia.
John FankhauserEternal Love Winning Africa Hospital, Monrovia, Liberia.
Bryn BurkholderWilmer Eye Institute, Johns Hopkins University Medical Center, Baltimore, MD, USA.
James PettittNational Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Robin GrossNational Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Tyler BradyNational Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Bonnie Dighero-KempNational Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Cavan ReillyDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Lisa HensleyNational Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Elizabeth HiggsNational Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Steven YehEmory Eye Center, Emory University School of Medicine, Atlanta, GA, USA.
Rachel J BishopNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
National Institute of Allergy and Infectious Diseases · USEmory University · USL V Prasad Eye Institute · INUniversity of Minnesota · USDuke University · USEmory Eye Center · USFrederick National Laboratory for Cancer Research · USJohns Hopkins University · USNational Eye Institute · USNational Institutes of Health · USOregon Health & Science University · USRetina Institute · USTenwek Hospital · KEUniversity Medical Center · USUniversity of Liberia · LR

Funding

Pathogenesis of Uveitis in Ebola Virus Disease SurvivorsR01EY029594 · NEI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI YEH, STEVEN · 2019 to 2023
$2.9M
Ophthalmic Disease and Laboratory Surveillance in a Viral Hemorrhagic Fever ZoneK23EY030158 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHANTHA, JESSICA · 2019 to 2023
$1.2M
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENEI NIH HHS K23 EY030158NEI NIH HHS R01 EY029594
6 · The paper itself

Abstract

Purpose: In survivors of Ebola virus disease (EVD), intraocular viral persistence raises questions about the timing and safety of cataract surgery. To the best of our knowledge, this is the first controlled study evaluating Ebola virus persistence and cataract surgery safety and outcomes in EVD survivors. Methods: Seropositive EVD survivors and seronegative controls with vision worse than 20/40 from cataract and without active intraocular inflammation were enrolled. Aqueous humor from survivors was tested with reverse transcription-polymerase chain reaction for Ebola viral RNA. Participants underwent manual small-incision cataract surgery and 1 year of follow-up examinations. Results: Twenty-two eyes of 22 survivors and 12 eyes of eight controls underwent cataract surgery. All of the aqueous samples tested negative for Ebola viral RNA. Median visual acuity improved from 20/200 at baseline to 20/25 at 1 year in survivors and from count fingers to 20/50 in controls (overall, Conclusions: EVD survivors and controls demonstrated significant visual improvement from cataract surgery. The persistence of intraocular inflammation highlights the importance of follow-up. The absence of detectable intraocular Ebola viral RNA provides guidance regarding the safety of eye surgery in Ebola survivors. Translational Relevance: These findings demonstrate the safety and efficacy of cataract surgery in Ebola survivors and will inform ocular surgery guidelines in this population.

Indexed as

CataractCataract ExtractionEbolavirusHemorrhagic Fever, EbolaHumansSurvivorscataract surgeryEbola virus diseaseuveitis, manual small incision cataract surgery

Identifiers

PMID33520427
PMCPMC7838547
OpenAlexW3125818595

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.