ArticleScience bulletin2021
A theoretical exploration of the origin and early evolution of a pandemic.
Article in Science bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Emergence of SARS and COVID-19 and preparedness for the next emerging disease X.Frontiers of medicine · 2024Review
- Intra- vs. Interhost Evolution of SARS-CoV-2 Driven by Uncorrelated Selection-The Evolution Thwarted.Molecular biology and evolution · 2023Article
- On the epicenter of COVID-19 and the origin of the pandemic strain.National science review · 2023Article
- Was Wuhan the early epicenter of the COVID-19 pandemic?-A critique.National science review · 2023Article
- Pinpointing the animal origins of SARS-CoV-2: a genomic approach.Journal of genetics and genomics = Yi chuan xue bao · 2022Article
- The twin-beginnings of COVID-19 in Asia and Europe-one prevails quickly.National science review · 2022Article
- The Runaway Evolution of SARS-CoV-2 Leading to the Highly Evolved Delta Strain.Molecular biology and evolution · 2022Article
- Waiting for the truth: is reluctance in accepting an early origin hypothesis for SARS-CoV-2 delaying our understanding of viral emergence?BMJ global health · 2022Review
- Evolutionary dynamics of the severe acute respiratory syndrome coronavirus 2 genomes.Medical review (2021) · 2022Review
- The adaptation of SARS-CoV-2 to humans.Memorias do Instituto Oswaldo Cruz · 2022Article
- On the origin of SARS-CoV-2-The blind watchmaker argument.Science China. Life sciences · 2021Article
- Possible Roles of Permafrost Melting, Atmospheric Transport, and Solar Irradiance in the Development of Major Coronavirus and Influenza Pandemics.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A virus that can cause a global pandemic must be highly adaptive to human conditions. Such adaptation is not likely to have emerged suddenly but, instead, may have evolved step by step with each step favored by natural selection. It is thus necessary to develop a theory about the origin in order to guide the search. Here, we propose such a model whereby evolution occurs in both the virus and the hosts (where the evolution is somatic; i.e., in the immune system). The hosts comprise three groups - the wild animal hosts, the nearby human population, and farther-away human populations. The theory suggests that the conditions under which the pandemic has initially evolved are: (i) an abundance of wild animals in the place of origin (PL
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.