Evidence map›Paper›PMID 33519780›Full record

ArticleFrontiers in microbiology2020

Mass Spectrometry Guided Discovery and Design of Novel Asperphenamate Analogs From

Karolina Subko, Xinhui Wang, Frederik H Nielsen, Thomas Isbrandt, Charlotte H Gotfredsen, Maria C Ramos, Thomas Mackenzie, Francisca Vicente, Olga Genilloud, Jens C Frisvad and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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  7. The Fungal EndophyteJournal of fungi (Basel, Switzerland) · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Karolina SubkoDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark.
Xinhui WangDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark.
Frederik H NielsenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark.
Thomas IsbrandtDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark.
Charlotte H GotfredsenDepartment of Chemistry, Technical University of Denmark, Lyngby, Denmark.
Maria C RamosFundación MEDINA, Granada, Spain.
Thomas MackenzieFundación MEDINA, Granada, Spain.
Francisca VicenteFundación MEDINA, Granada, Spain.
Olga GenilloudFundación MEDINA, Granada, Spain.
Jens C FrisvadDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark.
Thomas O LarsenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark.
Technical University of Denmark · DKFundación Medina · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asperphenamate is a small peptide natural product that has gained much interest due to its antitumor activity. In the recent years numerous bioactive synthetic asperphenamate analogs have been reported, whereas only a handful of natural analogs either of microbial or plant origin has been discovered. Herein we describe a UHPLC-HRMS/MS and amino acid supplement approach for discovery and design of novel asperphenamate analogs. Chemical analysis of

Indexed as

amino acid incorporationasperphenamatebiological activityfilamentous fungimass spectrometrynatural product discoveryNRPS flexibility

Identifiers

PMID33519780
PMCPMC7843940
OpenAlexW3118714698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.