Evidence map›Paper›PMID 33519557›Full record

ArticleFrontiers in psychiatry2020

Case Report: Lateral Habenula Deep Brain Stimulation for Treatment-Resistant Depression.

Zhiyan Wang, Xiaodong Cai, Rirang Qiu, Chen Yao, Ye Tian, Chen Gong, Yingli Zhang, Bin Xu, Doudou Zhang, Yu Zang and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  15. The Habenula in the Link Between ADHD and Mood Disorder.Frontiers in behavioral neuroscience · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhiyan WangNational Engineering Laboratory for Neuromodulation, Tsinghua University School of Aerospace Engineering, Tsinghua University, Beijing, China.
Xiaodong CaiDepartment of Neurosurgery, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Rirang QiuDepartment of Depressive Disorder, Shenzhen Mental Health Center, Shenzhen, China.
Chen YaoDepartment of Neurosurgery, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Ye TianNational Engineering Laboratory for Neuromodulation, Tsinghua University School of Aerospace Engineering, Tsinghua University, Beijing, China.
Chen GongNational Engineering Laboratory for Neuromodulation, Tsinghua University School of Aerospace Engineering, Tsinghua University, Beijing, China.
Yingli ZhangDepartment of Depressive Disorder, Shenzhen Mental Health Center, Shenzhen, China.
Bin XuDepartment of Neurosurgery, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Doudou ZhangDepartment of Neurosurgery, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Yu ZangDepartment of Depressive Disorder, Shenzhen Mental Health Center, Shenzhen, China.
Jiali LiuDepartment of Neurosurgery, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Bo PengDepartment of Depressive Disorder, Shenzhen Mental Health Center, Shenzhen, China.
Luming LiNational Engineering Laboratory for Neuromodulation, Tsinghua University School of Aerospace Engineering, Tsinghua University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment-resistant depression (TRD) is a chronic and severe psychiatric illness associated with limited therapeutic options. Deep brain stimulation (DBS) is a promising therapy for TRD patients. However, its safety and efficacy are still unclear. Here we reported the safety and efficacy of lateral habenula (LHb) DBS for a TRD patient who had failed medical, psychological, electroconvulsive, and ketamine therapy. The DBS system is compatible with 3T magnetic resonance imaging along with local field potential (LFP) streaming. Two DBS electrodes were implanted at the bilateral LHb without any complication. The patient showed acute stimulation effects and achieved long-term improvements in his depression, anxiety, and sleep with left LHb 160 Hz frequency stimulation, accompanying the change of LFPs. These results provided clinical evidence toward the safety and efficacy and electrophysiological basis of LHb DBS for TRD.

Indexed as

deep brain stimualtionlateral habenulalocal field potentialspatienttreatment resistant depression

Identifiers

PMID33519557
PMCPMC7838359

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.