Evidence map›Paper›PMID 33519531›Full record

ArticleFrontiers in physiology2020

Calcium-Sensing Receptor Participates in High Glucose-Induced EndMT in Primary Human Aortic Endothelial Cells.

Cheng Yuan, Lihua Ni, Xianqin Yang, Changjiang Zhang, Xiaoyan Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Cheng YuanDepartment of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Lihua NiDepartment of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Xianqin YangDepartment of Emergency, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, China.
Changjiang ZhangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Xiaoyan WuDepartment of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Wuhan University · CNThe Central Hospital of Enshi Tujia and Miao Autonomous Prefecture · CNZhongnan Hospital of Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePrevious studies have shown that high glucose (HG) induces endothelial cell (EC) damage via endothelial-to-mesenchymal transition (EndMT). Although the underlying mechanisms are still unclear, recent studies have demonstrated the role of calcium-sensing receptor (CaSR) in mediating EC damage. Therefore, the aim of our study was to investigate whether CaSR mediates HG-induced EndMT and to determine the underlying mechanism.

methodsBioinformatics analysis of microarray profiles (GSE30780) and protein-protein interaction (PPI) analyses were performed to select the hub genes. As for

resultsThe bioinformatics analysis indicated CaSR was significantly increased in HG-treated HAECs and was one of the hub genes. The

conclusionOur research demonstrated that HG-induced EndMT in HAECs might be mediated by CaSR and the downstream nuclear translocation of β-catenin.

Indexed as

bioinformatics analysiscalcium-sensing receptorendothelial to mesenchymal transitionhigh glucosehuman aortic endothelial cell

Identifiers

PMID33519531
PMCPMC7844313
OpenAlexW3120302452

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.