Evidence map›Paper›PMID 33519519›Full record

ArticleFrontiers in physiology2020

Antenatal Endotoxin Impairs Lung Mechanics and Increases Sensitivity to Ventilator-Induced Lung Injury in Newborn Rat Pups.

Erica W Mandell, Courtney Mattson, Gregory Seedorf, Sharon Ryan, Tania Gonzalez, Alison Wallbank, Elisa M Bye, Steven H Abman, Bradford J Smith

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Early dysanapsis in experimental bronchopulmonary dysplasia: implications for lifelong lung disease.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Antenatal Endotoxin Induces Dysanapsis in Experimental Bronchopulmonary Dysplasia.American journal of respiratory cell and molecular biology · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Erica W MandellDepartment of Pediatrics, Pediatric Heart Lung Center, School of Medicine, University of Colorado, Aurora, CO, United States.
Courtney MattsonDepartment of Bioengineering, College of Engineering, Design, and Computing, University of Colorado Denver | Anschutz Medical Campus, Aurora, CO, United States.
Gregory SeedorfDepartment of Pediatrics, Pediatric Heart Lung Center, School of Medicine, University of Colorado, Aurora, CO, United States.
Sharon RyanDepartment of Pediatrics, Pediatric Heart Lung Center, School of Medicine, University of Colorado, Aurora, CO, United States.
Tania GonzalezDepartment of Pediatrics, Pediatric Heart Lung Center, School of Medicine, University of Colorado, Aurora, CO, United States.
Alison WallbankDepartment of Bioengineering, College of Engineering, Design, and Computing, University of Colorado Denver | Anschutz Medical Campus, Aurora, CO, United States.
Elisa M ByeDepartment of Pediatrics, Pediatric Heart Lung Center, School of Medicine, University of Colorado, Aurora, CO, United States.
Steven H AbmanDepartment of Pediatrics, Pediatric Heart Lung Center, School of Medicine, University of Colorado, Aurora, CO, United States.
Bradford J SmithDepartment of Pediatrics, Pediatric Heart Lung Center, School of Medicine, University of Colorado, Aurora, CO, United States.
University of Colorado Denver · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Role of VEGF in Perinatal Pulmonary HypertensionR01HL068702 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ABMAN, STEVEN HERBERT, SHEPHERD, DOUGLAS · 2001 to 2021
$6.7M
Cardiovascular Biomechanics and Imaging in Down SyndromeT32HL072738 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SHANDAS, ROBIN · 2003 to 2025
$4.9M
NRSA Training CoreTL1TR002533 · NCATS · UNIVERSITY OF COLORADO DENVER · PI CICUTTO, LISA · 2018 to 2022
$3.0M
Role of Vitamin D in Lung Development and Bronchopulmonary DysplasiaK08HL150222 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MANDELL, ERICA WYNNE · 2020 to 2024
$809k
Role of VEGF in Perinatal HypertensionR56HL068702 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ABMAN, STEVEN HERBERT, SHEPHERD, DOUGLAS · 2018 to 2018
$765k
Spatiotemporal evolution of lung injury during ventilator-induced lung injuryF31HL149268 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MATTSON, COURTNEY · 2019 to 2021
$122k
NCATS NIH HHS TL1 TR002533NHLBI NIH HHS F31 HL149268NHLBI NIH HHS K08 HL150222NHLBI NIH HHS R01 HL068702NHLBI NIH HHS R56 HL068702NHLBI NIH HHS T32 HL072738
6 · The paper itself

Abstract

Perinatal inflammation due to chorioamnionitis and ventilator-induced lung injury (VILI) at birth is independent risk factors for the development of bronchopulmonary dysplasia (BPD). We have previously shown that antenatal endotoxin (ETX) causes abnormal lung structure and function in 2-week-old rats, but whether ETX impairs lung mechanics at birth and increases risk for VILI is unknown. Fetal rats were exposed to 10 μg endotoxin or saline

Indexed as

antenatal exposureendotoxinlung developmentlung structurenewborn rat ventilationventilator induced lung injury

Identifiers

PMID33519519
PMCPMC7838561
OpenAlexW3119968812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.