Evidence map›Paper›PMID 33519465›Full record

ArticleFrontiers in pharmacology2020

Discovery and Preclinical Development of Orally Active Small Molecules that Exhibit Highly Selective Follicle Stimulating Hormone Receptor Agonism.

Selva Nataraja, Henry Yu, Joie Guner, Stephen Palmer

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Allosteric modulation of gonadotropin receptors.Frontiers in endocrinology · 2023
    Review
  3. Article
  4. Follicle-Stimulating Hormone Induces Lipid DropletsFrontiers in endocrinology · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Selva NatarajaTocopheRx, Inc., Groton, MA, United States.
Henry YuTocopheRx, Inc., Groton, MA, United States.
Joie GunerCenter for Drug Discovery, Baylor College of Medicine, Houston, TX, United States.
Stephen PalmerTocopheRx, Inc., Groton, MA, United States.
Baylor College of Medicine · US

Funding

Targeting sperm-specific proteins during meiosis and sperm morphogenesisP01HD087157 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI GARCIA, THOMAS · 2017 to 2021
$6.2M
Functional analysis of novel testis-expressed secreted and transmembrane proteinsR01HD088412 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MARTIN M. MATZUK · 2016 to 2026
$4.5M
NICHD NIH HHS P01 HD087157NICHD NIH HHS R01 HD088412
6 · The paper itself

Abstract

An orally active follicle stimulating hormone receptor allosteric agonist would provide a preferred treatment for over 16 million infertile women of reproductive age in low complexity methods (ovulation induction-intrauterine insemination) or in high complexity methods (controlled ovarian stimulation-

Indexed as

follicle stimulating hormonefollicular maturationG-protein coupled receptorinfertility treatmentoocyte viabilityoral FSHR allosteric agonist

Identifiers

PMID33519465
PMCPMC7845544
OpenAlexW3119120854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.