ReviewFrontiers in cellular neuroscience2020
Structural and Functional Features of Developing Brain Capillaries, and Their Alteration in Schizophrenia.
Review in Frontiers in cellular neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Retinal and choroidal vascular density alterations in patients with schizophrenia: assessment via optical coherence tomography angiography.BMC psychiatry · 2026Article
- Reviewing vascular influences on neuronal migration, cortical development, and neurodevelopmental disorders: focus on autism, ADHD and schizophrenia.Molecular psychiatry · 2025Review
- Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depression.Cell & bioscience · 2025Review
- Bone marrow-derived myeloid cells transiently colonize the brain during postnatal development and interact with glutamatergic synapses.iScience · 2024Article
- Emerging epigenetic dynamics in gut-microglia brain axis: experimental and clinical implications for accelerated brain aging in schizophrenia.Frontiers in cellular neuroscience · 2023Review
- Neurovascular crosstalk and cerebrovascular alterations: an underestimated therapeutic target in autism spectrum disorders.Frontiers in cellular neuroscience · 2023Review
- Neurovascular coupling: motive unknown.Trends in neurosciences · 2022Review
- An Integrative Analysis of Identified Schizophrenia-Associated Brain Cell Types and Gene Expression Changes.International journal of molecular sciences · 2022Article
- Toward an integrative neurovascular framework for studying brain networks.Neurophotonics · 2022Article
- Schizophrenia in Translation: Why the Eye?Schizophrenia bulletin · 2022Article
- Abnormal corneal nerve morphology and brain volume in patients with schizophrenia.Scientific reports · 2022Article
- The implication of a diversity of non-neuronal cells in disorders affecting brain networks.Frontiers in cellular neuroscience · 2022Review
- Compositional Features and Nutritional Value of Pig Brain: Potential and Challenges as a Sustainable Source of Nutrients.Foods (Basel, Switzerland) · 2021Article
- Translational control in neurovascular brain development.Royal Society open science · 2021Review
- From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum.Frontiers in aging neuroscience · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia affects more than 1% of the world's population and shows very high heterogeneity in the positive, negative, and cognitive symptoms experienced by patients. The pathogenic mechanisms underlying this neurodevelopmental disorder are largely unknown, although it is proposed to emerge from multiple genetic and environmental risk factors. In this work, we explore the potential alterations in the developing blood vessel network which could contribute to the development of schizophrenia. Specifically, we discuss how the vascular network evolves during early postnatal life and how genetic and environmental risk factors can lead to detrimental changes. Blood vessels, capillaries in particular, constitute a dynamic and complex infrastructure distributing oxygen and nutrients to the brain. During postnatal development, capillaries undergo many structural and anatomical changes in order to form a fully functional, mature vascular network. Advanced technologies like magnetic resonance imaging and near infrared spectroscopy are now enabling to study how the brain vasculature and its supporting features are established in humans from birth until adulthood. Furthermore, the contribution of the different neurovascular unit elements, including pericytes, endothelial cells, astrocytes and microglia, to proper brain function and behavior, can be dissected. This investigation conducted among different brain regions altered in schizophrenia, such as the prefrontal cortex, may provide further evidence that schizophrenia can be considered a neurovascular disorder.
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