ArticleFrontiers in neuroscience2020
Intensity and Dose of Neuromuscular Electrical Stimulation Influence Sensorimotor Cortical Excitability.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07297381 (Neuromuscular Electrical Stimulation and Action Observation for Healthy Aging), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuromuscular Electrical Stimulation and Action Observation for Healthy Aging: a Home-based Approach to Promote Sensorimotor Adaptation
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Application of facial neuromuscular electrical stimulation (fNMES) in psychophysiological research: Practical recommendations based on a systematic review of the literature.Behavior research methods · 2024Guideline
- Trial
- Trial
- Acute changes in ankle dorsiflexor strength and fNIRS-Derived cortical activation following a single session of neuromuscular electrical stimulation in healthy older adults.Frontiers in aging · 2026Article
- Differential cortical responses to neuromuscular electrical vs. peripheral magnetic stimulation: a multimodal TMS-fNIRS study.Frontiers in neuroscience · 2026Article
- Sensorimotor Integration by Targeted Priming in Muscles with Electromyography-Driven Electro-vibro-feedback in Robot-Assisted Wrist/Hand Rehabilitation after Stroke.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Effectiveness of a trunk-wearable neuromuscular electrical stimulation device in postpartum women with diastasis rectus abdominis: A prospective randomized controlled trial.Wearable technologies · 2025Article
- Dual 500-μs wide pulse neuromuscular electrical stimulation enhancing sensorimotor cortical excitability.Frontiers in human neuroscience · 2025Article
- Altered network connectivity and global efficiency in tourette syndrome: insights into sensorimotor integration.NeuroImage. Clinical · 2025Article
- Bimanual coordination and spinal cord neuromodulation: how neural substrates of bimanual movements are altered by transcutaneous spinal cord stimulation.Journal of neuroengineering and rehabilitation · 2024Article
- Comparison of Immediate Neuromodulatory Effects between Focal Vibratory and Electrical Sensory Stimulations after Stroke.Bioengineering (Basel, Switzerland) · 2024Article
- Cortical activation of neuromuscular electrical stimulation synchronized mirror neuron rehabilitation strategies: an fNIRS study.Frontiers in neurology · 2023Article
- Cortical processing during robot and functional electrical stimulation.Frontiers in systems neuroscience · 2023Article
- A garment that measures brain activity: proof of concept of an EEG sensor layer fully implemented with smart textiles.Frontiers in human neuroscience · 2023Article
- A blended neurostimulation protocol to delineate cortico-muscular and spino-muscular dynamics following neuroplastic adaptation.Frontiers in neurology · 2023Article
- Challenges of neural interfaces for stroke motor rehabilitation.Frontiers in human neuroscience · 2023Article
- MCU-less biphasic electrical stimulation circuit for miniaturized neuromodulator.Biomedical engineering letters · 2022Article
- Effects of Electromyography Bridge on Upper Limb Motor Functions in Stroke Participants: An Exploratory Randomized Controlled Trial.Brain sciences · 2022Article
- Volunteers' concerns about facial neuromuscular electrical stimulation.BMC psychology · 2022Article
- Short-term facilitation effects elicited by cortical priming through theta burst stimulation and functional electrical stimulation of upper-limb muscles.Experimental brain research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuromuscular electrical stimulation (NMES) of the nervous system has been extensively used in neurorehabilitation due to its capacity to engage the muscle fibers, improving muscle tone, and the neural pathways, sending afferent volleys toward the brain. Although different neuroimaging tools suggested the capability of NMES to regulate the excitability of sensorimotor cortex and corticospinal circuits, how the intensity and dose of NMES can neuromodulate the brain oscillatory activity measured with electroencephalography (EEG) is still unknown to date. We quantified the effect of NMES parameters on brain oscillatory activity of 12 healthy participants who underwent stimulation of wrist extensors during rest. Three different NMES intensities were included, two below and one above the individual motor threshold, fixing the stimulation frequency to 35 Hz and the pulse width to 300 μs. Firstly, we efficiently removed stimulation artifacts from the EEG recordings. Secondly, we analyzed the effect of amplitude and dose on the sensorimotor oscillatory activity. On the one hand, we observed a significant NMES intensity-dependent modulation of brain activity, demonstrating the direct effect of afferent receptor recruitment. On the other hand, we described a significant NMES intensity-dependent dose-effect on sensorimotor activity modulation over time, with below-motor-threshold intensities causing cortical inhibition and above-motor-threshold intensities causing cortical facilitation. Our results highlight the relevance of intensity and dose of NMES, and show that these parameters can influence the recruitment of the sensorimotor pathways from the muscle to the brain, which should be carefully considered for the design of novel neuromodulation interventions based on NMES.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.