ArticleWorld journal of gastroenterology2021
Serum vitamin D and vitamin-D-binding protein levels in children with chronic hepatitis B.
Article in World journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Evaluating the role of resistive index in pediatric Hashimoto's thyroiditis diagnosis and the impact of vitamin D treatment on resistive index.BMC pediatrics · 2025Article
- The association between chronic liver disease and osteoporosis in East Asian populations: a bidirectional Mendelian randomization study.Aging clinical and experimental research · 2025Article
- Vitamin D and Molecules Related to Vitamin D Metabolism in Children with Sepsis.Journal of inflammation research · 2024Article
- Association of vitamin D and polymorphisms of its receptor with antiviral therapy in pregnant women with hepatitis B.World journal of gastroenterology · 2023Article
- The Role of Vitamin D and Vitamin D Binding Protein in Chronic Liver Diseases.International journal of molecular sciences · 2022Review
- Potential roles of vitamin D binding protein in attenuating liver injury in sepsis.Military Medical Research · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin D is an essential fat-soluble secosteroid hydroxylated by the liver to form the intermediate metabolite calcidiol {25-hydroxy vitamin D [25(OH)D]}, which is a reliable indicator to investigate individual vitamin D status. Vitamin-D-binding protein (VDBP) is a multifunctional glycoprotein mainly synthesized in the liver and the major transport protein for vitamin D and its metabolites. Serum vitamin D and VDBP are both associated with hepatitis B. However, few studies have reported the relationship and clinical significance of vitamin D and VDBP with hepatitis B virus (HBV) replication and hepatic fibrosis in children with chronic hepatitis B (CHB).
aimTo explore vitamin D and VDBP serum levels in children with CHB and the association of vitamin D and VDBP with HBV replication and hepatic fibrosis.
methodsWe enrolled 204 children with CHB admitted to Hunan Children' Hospital in summer and autumn between 2018 and 2019 and 170 healthy controls. CHB patients included: 164 hepatitis B e antigen (HBeAg) positive and 40 HBeAg negative; 193 hepatitis B surface antigen (HBsAg) positive and 11 HBsAg negative; 164 with detectable HBV deoxyribonucleic acid (DNA) and 40 with undetectable HBV DNA; 131 with HBV genotype B and 23 with HBV genotype C; and 27 without hepatic fibrosis and 97 with hepatic fibrosis. Serum levels of 25(OH)D, VDBP, liver function markers, and other clinical parameters were collected to analyze their association with vitamin D and VDBP. Mann-Whitney
resultsChildren with CHB had lower serum 25(OH)D (56.64 ± 17.89 nmoL/L) and VDBP [122.40 (70.74-262.84 μg/L)] levels than healthy controls had (
conclusionSerum levels of 25(OH)D and VDBP are decreased in children with CHB. Serum VDBP level is negatively correlated with HBV replication. Low level of 25(OH)D is independently associated with hepatic fibrosis in children with CHB. There is no significant association between serum levels of 25(OH)D and VDBP.
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