ArticleJournal of epidemiology2022
Longitudinal Association Between Oral Status and Cognitive Decline Using Fixed-effects Analysis.
Article in Journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Periodontal health, cognitive decline, and dementia: A systematic review and meta-analysis of longitudinal studies.Journal of the American Geriatrics Society · 2022Pooled it
- A global mapping of research on the relationship between oral health and nutritional status.BDJ open · 2026Article
- Association Between Oral Frailty and Cognitive Impairment in Older Adults: A Cross-sectional Study.International dental journal · 2026Article
- Longitudinal association between oral health and dementia among older adults: evidence from the Korean longitudinal study of ageing.BMC geriatrics · 2026Article
- Predictive factors for dementia among older adults in South Korea: an interpretable machine learning analysis.Alzheimer's research & therapy · 2025Article
- Barriers to oral health management in inpatients with late-life depression: a qualitative study.BMC oral health · 2025Article
- Contribution of dental prostheses on the association between dental visits and self- reported chewing ability among older Japanese adults: a cross-sectional study.BMC oral health · 2025Article
- Perceived indoor thermal environment and depressive symptoms among older adults in the Japan Gerontological Evaluation Study.Scientific reports · 2025Article
- Effects of Information and Communication Technology Use on the Executive Function of Older Adults without Dementia: A Longitudinal Fixed-Effect Analysis.Annals of geriatric medicine and research · 2024Article
- The potential positive effect of periodontal treatment on brain function activity using functional magnetic resonance imaging analysis.Journal of dental sciences · 2024Article
- Association Between Subjective Masticatory Function and Mild Cognitive Impairment in Older Adults.International dental journal · 2024Article
- Health-related quality of life in various health conditions: two consecutive surveys of older Japanese adults.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Associations Between Abdominal Obesity, Chewing Difficulty and Cognitive Impairment in Dementia-Free Chinese Elderly.American journal of Alzheimer's disease and other dementiasArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the feasibility of randomized trials for investigating the long-term association between oral health and cognitive decline is low, deriving causal inferences from observational data is challenging. We aimed to investigate the association between poor oral status and subjective cognitive complaints (SCC) using fixed-effects model to eliminate the confounding effect of unobserved time-invariant factors.
methodsWe used data from Japan Gerontological Evaluation Study (JAGES) which was conducted in 2010, 2013, and 2016. β regression coefficients and 95% confidence intervals [CIs] were calculated using fixed-effects models to determine the effect of deteriorating oral status on developing SCC. Onset of SCC was evaluated using the Kihon Checklist-Cognitive function score. Four oral status variables were used: awareness of swallowing difficulty, decline in masticatory function, dry mouth, and number of teeth.
resultsWe included 13,594 participants (55.8% women) without SCC at baseline. The mean age was 72.4 (standard deviation [SD], 5.1) years for men and 72.4 (SD, 4.9) years for women. Within the 6-year follow-up, 26.6% of men and 24.9% of women developed SCC. The probability of developing SCC was significantly higher when participants acquired swallowing difficulty (β = 0.088; 95% CI, 0.065-0.111 for men and β = 0.077; 95% CI, 0.057-0.097 for women), decline in masticatory function (β = 0.039; 95% CI, 0.021-0.057 for men and β = 0.030; 95% CI, 0.013-0.046 for women), dry mouth (β = 0.026; 95% CI, 0.005-0.048 for men and β = 0.064; 95% CI, 0.045-0.083 for women), and tooth loss (β = 0.043; 95% CI, 0.001-0.085 for men and β = 0.058; 95% CI, 0.015-0.102 for women).
conclusionThe findings suggest that good oral health needs to be maintained to prevent the development of SCC, which increases the risk for future dementia.
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