Evidence map›Paper›PMID 33518580›Full record

ArticleInternal medicine (Tokyo, Japan)2021

Japanese Man with HCV Genotype 4 Infection and Cirrhosis Who Was Successfully Treated by the Combination of Glecaprevir and Pibrentasvir.

Mai Totsuka, Masayuki Honda, Tatsuo Kanda, Tomotaka Ishii, Naoki Matsumoto, Yoichiro Yamana, Tomohiro Kaneko, Taku Mizutani, Hiroshi Takahashi, Mariko Kumagawa and 9 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Mai TotsukaDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
Masayuki HondaDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
Tatsuo KandaDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
Tomotaka IshiiDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
Naoki MatsumotoDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
Yoichiro YamanaDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
Tomohiro KanekoDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
Taku MizutaniDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
Hiroshi TakahashiDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
Mariko KumagawaDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
Reina SasakiDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
Ryota MasuzakiDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
Shini KanezawaDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
Kazushige NireiDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
Hiroaki YamagamiDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
Shunichi MatsuokaDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
Hiroshi OhnishiDivision of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Japan.
Hiroaki OkamotoDivision of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Japan.
Mitsuhiko MoriyamaDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
Nihon University · JPJichi Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 74-year-old man with a history of transfusion at 35 years old in Egypt was referred to our hospital. He was infected with hepatitis C virus (HCV) genotype 4 (GT4), which is a rare HCV GT in Japan, and was also diagnosed with hepatic compensated cirrhosis. We safely treated the patient for 12 weeks with the combination of glecaprevir and pibrentasvir, and a sustained virologic response (SVR) was achieved. This is the first report of HCV GT4 infection in a treatment-naïve Japanese patient with cirrhosis in whom SVR was achieved with the combination treatment of glecaprevir and pibrentasvir.

Indexed as

HepacivirusHepatitis C, ChronicAdultAgedAntiviral AgentsBenzimidazolesDrug CombinationsDrug Therapy, CombinationGenotypeHumansJapanLiver CirrhosisMalePyrrolidinesQuinoxalinesSulfonamidesAntiviral AgentsBenzimidazolesDrug Combinationsglecaprevir and pibrentasvirPyrrolidinesQuinoxalinesSulfonamidescirrhosisDAAHCV genotype 4Japantransfusion

Identifiers

PMID33518580
PMCPMC8313908
OpenAlexW3128876196

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.