Evidence map›Paper›PMID 33518570›Full record

ArticleInternal medicine (Tokyo, Japan)2021

An Autopsy Case of Primary Biliary Cholangitis with Histological Submassive Hepatic Necrosis Caused by Acute Hepatitis E Virus Infection.

Mizuki Koyama, Tomoo Yamazaki, Satoru Joshita, Akihiro Ito, Kazuyuki Ono, Takayuki Watanabe, Yuki Yamashita, Ayumi Sugiura, Mikiko Kobayashi, Yoshinori Sato and 3 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Mizuki KoyamaDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Japan.
Tomoo YamazakiDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Japan.
Satoru JoshitaDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Japan.
Akihiro ItoDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Japan.
Kazuyuki OnoDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Japan.
Takayuki WatanabeDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Japan.
Yuki YamashitaDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Japan.
Ayumi SugiuraDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Japan.
Mikiko KobayashiDepartment of Pathology, Shinshu University School of Medicine, Japan.
Yoshinori SatoDepartment of Pathology, Shinshu University School of Medicine, Japan.
Masaharu TakahashiDivision of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Japan.
Hiroaki OkamotoDivision of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Japan.
Takeji UmemuraDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Japan.
Shinshu University · JPJichi Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 59-year-old woman who had been diagnosed with cirrhotic primary biliary cholangitis (PBC) 5 years earlier was admitted for severe jaundice (total bilirubin: 30.1 mg/dL). We suspected that her cirrhotic PBC had deteriorated acutely for some reason. Her general condition deteriorated quickly, and she passed away on day 18 of admission. Hepatitis E virus (HEV)-IgA antibodies were positive, and Genotype 3b HEV involvement was confirmed from a blood sample taken on admission. Histopathological findings revealed cirrhosis and submassive loss and necrosis of hepatocytes. Clinicians should consider the possibility of acute HEV infection as a trigger for acute PBC exacerbation.

Indexed as

CholangitisHepatitis EHepatitis E virusLiver Cirrhosis, BiliaryMassive Hepatic NecrosisAutopsyFemaleHumansMiddle Agedhepatitis E virusprimary biliary cholangitis

Identifiers

PMID33518570
PMCPMC8263169
OpenAlexW3128074871

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.