Observational studyJournal of atherosclerosis and thrombosis2022
Clinical Impact of Measures for Frailty Severity in Poor-Risk Patients Undergoing Revascularization for Chronic Limb-Threatening Ischemia.
Observational study in Journal of atherosclerosis and thrombosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Contemporary outcomes of a DCB-based strategy with selective stent implantation for femoropopliteal artery lesions: results from the REAL-LEAD registry.CVIR endovascular · 2026Article
- Frailty Progression in Chronic Limb-threatening Ischemia: A Dynamic Target for Comprehensive Care.Journal of atherosclerosis and thrombosis · 2026Article
- Controlled Nutritional Status Scores and Bleeding Events in Lower Extremity Arterial Disease - 3-Year Clinical Outcome Study.Circulation reports · 2025Article
- Impact of Dementia on the Outcome of Surgical Revascularization for Chronic Limb-Threatening Ischemia.Annals of vascular diseases · 2025Article
- Wound formation in patients with Rutherford category IV disease after endovascular therapy: rates and risk factors.CVIR endovascular · 2024Article
- Association of Smoking, Diabetes, and Dialysis with the Presence of Popliteal Lesions in Femoropopliteal Artery Disease.Journal of atherosclerosis and thrombosis · 2023Article
- Prognostic Value of Hospital Frailty Risk Score and Clinical Outcomes in Patients Undergoing Revascularization for Critical Limb-Threatening Ischemia.Journal of the American Heart Association · 2023Article
- Injury Precipitating Tissue Loss and Time to Referral to a Vascular Center in Patients with Chronic Limb-Threatening Ischemia.Journal of atherosclerosis and thrombosis · 2023Article
- Weight Change Since Age 20 and the Risk of Cardiovascular Disease Mortality: A Prospective Cohort Study.Journal of atherosclerosis and thrombosis · 2022Article
- Measurement of Nutritional Status as Frailty Severity is Indispensable to Treat Patients with Chronic Limb-Threatening Ischemia.Journal of atherosclerosis and thrombosis · 2022Article
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Authors and funding
5 authors.
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Abstract
aimThis study aimed to demonstrate the clinical impact of various frailty-related aspects in poor-risk patients undergoing revascularization for chronic limb-threatening ischemia (CLTI).
methodsWe analyzed a clinical database of a prospective multicenter observational study. A total of 562 CLTI patients who required assistance for their daily lives and were candidates for revascularization were included. We examined various measures of frailty severity, including activities of daily living (ADL)/mobility, physical performance, nutritional status, cognitive function, and cardiac function at baseline (before revascularization). Data on inflammatory markers at baseline and ADL/mobility before CLTI onset were also collected.
resultsThe patients were aged 77±10 years, 65% were non-ambulatory, and 38% were categorized as mild dementia or severer. The correlation coefficients between the frailty measures ranged from 0.00 to 0.91. The random forest analysis for one-year mortality risk showed that these frailty-related measures, as well as age and inflammatory markers, had a relatively high variable importance compared with comorbidities and limb severity.
conclusionThe correlations between measures of frailty severity were not always strong but rather widely varied in CLTI patients who required assistance for their daily lives and were candidates for revascularization. Measures of frailty severity, as well as age and inflammatory markers, had a relatively large predictive impact on one-year mortality risk compared with comorbidities and limb severity in the population.
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