ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2022
Direct and Indirect Associations of Widespread Individual Differences in Brain White Matter Microstructure With Executive Functioning and General and Specific Dimensions of Psychopathology in Children.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Article
- Cerebellar Functional Alterations During Executive Functioning Are Associated With General Psychopathology in a Cross-Diagnostic Sample.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Untangling relationships between cognitive development and child and adolescent mental health: Findings from the ABCD Study.Developmental cognitive neuroscience · 2026Review
- Prenatal neural network organization and later executive function development.Developmental cognitive neuroscience · 2026Article
- Alterations in resting-state functional connectivity relate to psychopathology trajectories during emerging adolescence.JCPP advances · 2026Article
- Highly replicable multisite patterns of adolescent white matter maturation.bioRxiv : the preprint server for biology · 2026Article
- What we have learned about adolescent mental health and where we are going after a decade with the Adolescent Brain Cognitive Development Study.Developmental cognitive neuroscience · 2026Review
- Deviation in development of dorsal association tracts during preadolescence links to concurrent and future cognitive performance and transdiagnostic psychopathology.Nature communications · 2026Article
- Changes in white matter volume and cortical thickness predict internalizing symptoms during early adolescence.Journal of psychopathology and clinical science · 2026Article
- Psychiatric neuroimaging at a crossroads: Insights from psychiatric genetics.Developmental cognitive neuroscience · 2024Review
- Psychiatric Symptoms, Cognition, and Symptom Severity in Children.JAMA psychiatry · 2024Article
- Executive functioning, behavior, and white matter microstructure in the chronic phase after pediatric mild traumatic brain injury: results from the adolescent brain cognitive development study.Psychological medicine · 2024Article
- Executive Function as an Underlying Mechanism of Alcohol Use, Aggression, and ADHD.medRxiv : the preprint server for health sciences · 2024Article
- White matter microstructure, traumatic brain injury, and disruptive behavior disorders in girls and boys.Frontiers in neuroscience · 2024Article
- Person-centred Approaches to Psychopathology in the ABCD Study: Phenotypes and Neurocognitive Correlates.Research on child and adolescent psychopathology · 2023Article
- Early executive control buffers risk for adolescent psychopathology during the COVID-19 pandemic.Journal of adolescence · 2023Article
- Brain Structure Relations With Psychopathology Trajectories in the ABCD Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Atypical Functional Network Properties and Associated Dimensions of Child Psychopathology During Rest and Task Performance.Biological psychiatry global open science · 2023Article
- Polygenic risk scores and brain structures both contribute to externalizing behavior in childhood - A study in the Adolescent Brain and Cognitive Development (ABCD) cohort.Neuroscience applied · 2023Article
- Associations of polygenic risk for attention-deficit/hyperactivity disorder with general and specific dimensions of childhood psychological problems and facets of impulsivity.Journal of psychiatric research · 2022Article
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14 authors.
Funding
Abstract
backgroundExecutive functions (EFs) are important partly because they are associated with risk for psychopathology and substance use problems. Because EFs have been linked to white matter microstructure, we tested the prediction that fractional anisotropy (FA) and mean diffusivity (MD) in white matter tracts are associated with EFs and dimensions of psychopathology in children younger than the age of widespread psychoactive substance use.
methodsParent symptom ratings, EF test scores, and diffusion tensor parameters from 8588 9- to 10-year-olds in the ABCD Study (Adolescent Brain Cognitive Development Study) were used.
resultsA latent factor derived from EF test scores was significantly associated with specific conduct problems and attention-deficit/hyperactivity disorder problems, with dimensions defined in a bifactor model. Furthermore, EFs were associated with FA and MD in 16 of 17 bilateral white matter tracts (range: β = .05; SE = .17; through β = -.31; SE = .06). Neither FA nor MD was directly associated with psychopathology, but there were significant indirect associations via EFs of both FA (range: β = .01; SE = .01; through β = -.09; SE = .02) and MD (range: β = .01; SE = .01; through β = .09; SE = .02) with both specific conduct problems and attention-deficit/hyperactivity disorder in all tracts except the forceps minor.
conclusionsEFs in children are inversely associated with diffusion tensor imaging measures in nearly all tracts throughout the brain. Furthermore, variance in diffusion tensor measures that is shared with EFs is indirectly shared with attention-deficit/hyperactivity disorder and conduct problems.
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