ReviewPoultry science2021
Centennial Review: The chicken yolk sac is a multifunctional organ.
Review in Poultry science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 65 citations in OpenAlex.
- A rapid yolk-sac serum extraction method for quantifying maternal IgY of individual birds.MethodsX · 2026Article
- Effects of protease and lipase supplementation in starter diet on growth performance, small intestine morphology, and immunity in young broilers.Veterinary and animal science · 2026Article
- Maternal methionine supplementation regulates skeletal muscle development through NAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Changes in the chick liver structure and blood plasma biochemical properties following in ovo administration of acrylamide.Poultry science · 2026Article
- Transcriptomic analysis reveals a crucial role of the yolk sac during Avian Pathogenic Escherichia coli infection in chicken embryos.Poultry science · 2026Article
- A Bird's Eye View: A Close Look into Avian CAM Models for Translational Blood Cancer Research.Cancers · 2026Review
- Enhanced Macrophage and Granulocytic Recruitment with Increased Neo-Angiogenesis in Chicken Embryo Yolk Sac Following In Ovo Probiotic Blend Administration.Veterinary sciences · 2025Article
- Article
- Assessing the Genetic and Environmental Factors on Egg Amino Acid Traits in Chickens: A Review.Animals : an open access journal from MDPI · 2025Review
- The avian embryo as a time-honoured animal model in developmental, biomedical and agricultural research.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- In ovo delivery of carvacrol triggers expression of chemotactic factors, antimicrobial peptides and pro-inflammatory pathways in the yolk sac of broiler chicken embryos.Journal of animal science and biotechnology · 2025Article
- The journey of a lifetime: reflections on my career.Frontiers in physiology · 2025Article
- Influence of a multi-strain probiotic and zinc-glycine chelate, administeredFrontiers in physiology · 2025Article
- Embryo thermal manipulation modifies development and hepatic lipid metabolism in post-hatch layer-type chicks.Journal of animal science · 2024Article
- Effects of surface sterilization of fertile eggs on the yolk microbiota during the chicken embryo development.Frontiers in veterinary science · 2024Article
- Prolonged fasting induces significant germ cell loss in chickens after hatching.Poultry science · 2023Article
- Developmental changes in lipid and fatty acid metabolism and the inhibition by in ovo feeding oleic acid in Muscovy duck embryogenesis.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Supply and demand of creatine and glycogen in broiler chicken embryos.Frontiers in physiology · 2023Article
- Gluconeogenesis in the Yolk Sac Membrane: Enzyme Activity, Gene Expression, and Metabolites During Layer Chicken Development.The journal of poultry science · 2023Article
- The yolk sac as the main organ in the early stages of animal embryonic development.Frontiers in physiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The yolk sac (YS) consists of the yolk, which supplies nutrients, and the YS tissue, which surrounds the yolk and provides essential metabolic functions for the developing embryo. The YS tissue is derived from the midgut of the embryo and consists of a layer of endodermal epithelial cells (EEC) in contact with the yolk contents, a mesodermal layer that contains the vascular system and an outer ectodermal layer. The YS tissue is a multifunctional organ that provides essential functions such as host immunity, nutrient uptake, carbohydrate and lipid metabolism, and erythropoiesis. The YS tissue plays a role in immunity by the transport of maternal antibodies in the yolk to the embryonic circulation that feeds the developing embryo. In addition, the YS tissue expresses high mRNA levels of the host defense peptide, avian β-defensin 10 during mid embryogenesis. Owing to its origin, the YS EEC share some functional properties with intestinal epithelial cells such as expression of transporters for amino acids, peptides, monosaccharides, fatty acids, and minerals. The YS tissue stores glycogen and expresses enzymes for glycogen synthesis and breakdown and glucogenesis. This carbohydrate metabolism may play an important role in the hatching process. The mesodermal layer of the YS tissue is the site for erythropoiesis and provides erythrocytes before the maturation of the bone marrow. Other functions of the YS tissue involve synthesis of plasma proteins, lipid transport and cholesterol metabolism, and synthesis of thyroxine. Thus, the YS is an essential organ for the growth, development, and health of the developing embryo. This review will provide an overview of the studies that have investigated the functionalities of the YS tissue at the cellular and molecular levels with a focus on chickens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.