ArticlePublic health nutrition2021
Exposure to aflatoxins and fumonisins and linear growth of children in rural Ethiopia: a longitudinal study.
Article in Public health nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- A systematic review with meta-analysis of the relation of aflatoxin B1 to growth impairment in infants/children.BMC pediatrics · 2023Pooled it
- The Difficulties in Demonstrating That Aflatoxin Reduction Improves Stunting in Developing World Regions.Toxins · 2026Review
- Correlations of Aflatoxin Exposure from Cooking Oil and Dietary Foods During Pregnancy with Birth Weight and Gestational Age at Birth in Guangxi, China.International journal of general medicine · 2024Article
- Article
- Article
- Human Breast Milk Contamination with Aflatoxins, Impact on Children's Health, and Possible Control Means: A Review.International journal of environmental research and public health · 2022Review
- Harvest and post-harvest handling practices associated with fumonisin BMycotoxin research · 2022Article
- Stunting and Underweight, but not Wasting are Associated with Delay in Child Development in Southwest Ethiopia.Pediatric health, medicine and therapeutics · 2022Article
- Evidence-based strategies needed to combat malnutrition in Sub-Saharan countries facing different stages of nutrition transition.Public health nutrition · 2021Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe hypothesise that exposure to aflatoxins and fumonisins, measured in serum, alters protein synthesis, reducing serum protein and insulin-like growth factor 1 (IGF-1), increasing inflammation and infection, leading to child's linear growth failure.
designChildren 6-35 months, stratified by baseline stunting, were subsampled from an intervention trial on quality protein maize consumption and evaluated at two time-points.
settingBlood samples and anthropometric data were collected in the pre-harvest (August-September 2015) and post-harvest (February 2016) seasons in rural Ethiopia.
participants102 children (50 stunted and 52 non-stunted).
resultsProportions of children exposed to aflatoxin G1, aflatoxin G2 and aflatoxin M1 were higher in the pre-harvest (8, 33 and 7, respectively) compared to post-harvest season (4, 28 and 4, respectively). The proportion of children exposed to any aflatoxin was higher in the pre-harvest than post-harvest season (51 % v. 41 %). Fumonisin exposure ranged from 0 % to 11 %. In joint statistical tests, aflatoxin exposure was associated with serum biomarkers of inflammation (C-reactive protein, α-1-glycoprotein) and protein status (transthyretin, lysine, tryptophan), IGF-1 and linear growth (all P < 0·01). However, exposure to specific aflatoxins was not significantly associated with any biomarkers or outcomes (all P > 0·05).
conclusionsAflatoxin exposure among rural Ethiopian children was high, with large variation between seasons and individual aflatoxins. Fumonisin exposure was low. There was no clear association between aflatoxin exposure and protein status, inflammation or linear growth. A larger study may be needed to examine the potential biological interactions, and the assessment of aflatoxins in food is needed to determine sources of high exposure.
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