Evidence map›Paper›PMID 33517933›Full record

ArticleParasitology2021

Therapeutic efficacy of mebendazole and artemisinin in different phases of trichinellosis: a comparative experimental study.

Amal Farahat Allam, Reham Ahmed Mostafa, Wael Lotfy, Hoda Fahmy Farag, Naglaa Fathi, Esraa Abdelhamid Moneer, Amel Youssef Shehab

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasitology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Evaluation of the Efficacy of Anthelmintic Drugs AgainstAntibiotics (Basel, Switzerland) · 2026
    Article
  2. The Beneficial Use ofAnimals : an open access journal from MDPI · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Amal Farahat AllamMedical Research Institute, University of Alexandria, Department, Alexandria, Egypt.ORCID 0000-0002-4965-9469
Reham Ahmed MostafaDepartment of chemistry, Faculty of Education, Alexandria University, Alexandria, Egypt.
Wael LotfyFaculty of Nursing, Matrouh University, Matrouh, Egypt.
Hoda Fahmy FaragMedical Research Institute, University of Alexandria, Department, Alexandria, Egypt.
Naglaa FathiMedical Research Institute, University of Alexandria, Department, Alexandria, Egypt.
Esraa Abdelhamid MoneerDepartment of Medical Laboratory, Faculty of Allied Medical Sciences, Pharos University, Alexandria, Egypt.
Amel Youssef ShehabMedical Research Institute, University of Alexandria, Department, Alexandria, Egypt.
Alexandria University · EGEgypt Nanotechnology Center · EGPharos University in Alexandria · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present work aimed at studying the efficacy of mebendazole (MBZ) compared to artemisinin (ART) for the treatment of trichinellosis at various phases of infection. Seventy Swiss albino mice were orally infected by 300 Trichinella spiralis (T. spiralis) larvae. Mice were divided into infected untreated control group and infected groups treated with 50 mg kg-1 MBZ and 300 mg kg-1 ART for three and five consecutive days, respectively, at the enteral phase [2-4 days post infection (PI)], invasive phase (10-12 days PI) and encapsulated phase (28-30 days PI). All mice were sacrificed 35-42 days PI. MBZ and ART revealed a significant decrease in mean larval counts and increase of larval per cent reduction (LR %) when treatment was initiated during the enteral phase compared to the other phases. MBZ showed significantly higher LR % (99.7, 83.95 and 89.65%) than ART (80.58, 67.0 and 79.2%) when administered at the three infection phases. Histopathological study showed a decrease in the number of encysted larvae, their surrounding cellular infiltrates and increased regenerative muscles in all treated mice. In conclusion, ART possesses a substantial anthelmintic activity against T. spiralis infection in mice both at the enteral and encapsulated phases, yet, significantly lower than MBZ.

Indexed as

AnimalsAnthelminticsArtemisininsLarvaMebendazoleMiceTrichinella spiralisTrichinellosisAnthelminticsartemisininArtemisininsMebendazoleArtemisininencysted larvaemebendazolemiceTrichinella spiralis

Identifiers

PMID33517933
PMCPMC10950373
OpenAlexW3119913099

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.