ArticleMicrobiome2021
Toothbrush microbiomes feature a meeting ground for human oral and environmental microbiota.
Article in Microbiome, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Plaque Removal and Gingival Bleeding Using Biodegradable Toothbrushes: Salvadora persica, Bamboo, and Nylon: A Comparative Study.Medical science monitor : international medical journal of experimental and clinical research · 2024Trial
- Dental Plaque Removal with Two Special Needs Toothbrushes in Patients with Down Syndrome: A Parallel-Group Randomised Clinical Trial of Efficacy.Oral health & preventive dentistry · 2022Trial
- The Effect of 6-Week Advanced Oral Care on Oral Microbiome and Mycobiome Composition in People With Dementia Living in Residential Aged Care.Clinical and experimental dental research · 2025Article
- Epidemiological surveys, antibiotic resistance, and related risk factors of Helicobacter pylori in Quanzhou, China: a cross-sectional study.Scientific reports · 2025Article
- Alteration of salivaryFrontiers in pharmacology · 2025Article
- The indoors microbiome and human health.Nature reviews. Microbiology · 2024Review
- Assessing oral and toothbrush microbial profiles among high-altitude individuals with and without periodontal disease: a case-control study.BMC oral health · 2024Article
- Assessing Antibiotic-Resistant Genes in University Dormitory Washing Machines.Microorganisms · 2024Article
- Comparison of DNA extraction methods on different sample matrices within the same terrestrial ecosystem.Scientific reports · 2024Article
- Phage communities in household-related biofilms correlate with bacterial hosts.Frontiers in microbiomes · 2024Article
- In Vitro Efficacy of Domestic Techniques for Disinfection of Toothbrushes Contaminated WithInternational journal of dentistry · 2024Article
- Pseudomonadota in the oral cavity: a glimpse into the environment-human nexus.Applied microbiology and biotechnology · 2023Review
- An improved workflow for accurate and robust healthcare environmental surveillance using metagenomics.Microbiome · 2022Article
- Study of oral microbiota diversity among groups of families originally from different countries.Saudi journal of biological sciences · 2022Article
- Crosstalk between gut microbiota and renal ischemia/reperfusion injury.Frontiers in cellular and infection microbiology · 2022Review
- Profile of the oral microbiota from preconception to the third trimester of pregnancy and its association with oral hygiene practices.Journal of oral microbiology · 2022Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundWhile indoor microbiomes impact our health and well-being, much remains unknown about taxonomic and functional transitions that occur in human-derived microbial communities once they are transferred away from human hosts. Toothbrushes are a model to investigate the potential response of oral-derived microbiota to conditions of the built environment. Here, we characterize metagenomes of toothbrushes from 34 subjects to define the toothbrush microbiome and resistome and possible influential factors.
resultsToothbrush microbiomes often comprised a dominant subset of human oral taxa and less abundant or site-specific environmental strains. Although toothbrushes contained lower taxonomic diversity than oral-associated counterparts (determined by comparison with the Human Microbiome Project), they had relatively broader antimicrobial resistance gene (ARG) profiles. Toothbrush resistomes were enriched with a variety of ARGs, notably those conferring multidrug efflux and putative resistance to triclosan, which were primarily attributable to versatile environmental taxa. Toothbrush microbial communities and resistomes correlated with a variety of factors linked to personal health, dental hygiene, and bathroom features.
conclusionsSelective pressures in the built environment may shape the dynamic mixture of human (primarily oral-associated) and environmental microbiota that encounter each other on toothbrushes. Harboring a microbial diversity and resistome distinct from human-associated counterparts suggests toothbrushes could potentially serve as a reservoir that may enable the transfer of ARGs. Video abstract.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.