ArticleBorderline personality disorder and emotion dysregulation2021
Psychosocial stress increases testosterone in patients with borderline personality disorder, post-traumatic stress disorder and healthy participants.
Article in Borderline personality disorder and emotion dysregulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Impact of BRACTS exercises on muscular strength in eumenorrheic women.Scientific reports · 2025Trial
- Positive association between sex hormones and inflammatory cytokines in trauma-exposed premenopausal women.Brain, behavior, & immunity - health · 2026Article
- Testosterone in patients with borderline personality disorder: from hair analyses to social behavior.Comprehensive psychoneuroendocrinology · 2026Review
- Plasma Allopregnanolone and Sex Hormone Responses to Stress Induction: Contributors to the Formation of Intrusive Memories.Neuropsychobiology · 2026Article
- The Association of Cortisol and Testosterone Interaction With Inpatient Violence: Examining the Dual-Hormone Hypothesis in a Psychiatric Setting.Aggressive behavior · 2025Article
- Little evidence that posttraumatic stress is associated with diurnal hormone dysregulation in Turkana pastoralists.Evolution, medicine, and public health · 2025Article
- Stress, hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis, and aggression.Metabolic brain disease · 2024Review
- Hemodialysis does not lower circulating testosterone concentrations.Journal of nephrology · 2024Article
- The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications.Frontiers in neuroendocrinology · 2024Review
- Exploring the influence of stress on aggressive behavior and sexual function: Role of neuromodulator pathways and epigenetics.Heliyon · 2024Review
- Salivary testosterone is associated with feelings of senselessness and self-dislike in women with borderline personality disorder.European journal of psychotraumatology · 2024Article
- Depression in adolescence and young adulthood: the difficulty to integrate motivational/emotional systems.Frontiers in psychology · 2024Review
- Maternal steroids during pregnancy and their associations with exposure to lifetime stressful life events, prenatal stress appraisal and psychological functioning.Psychoneuroendocrinology · 2023Article
- Article
- Stimulating research on childhood adversities, borderline personality disorder, and complex post-traumatic stress disorder.Borderline personality disorder and emotion dysregulation · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe gonadal hormone testosterone not only regulates sexual behavior but is also involved in social behavior and cognition in both sexes. Changes in testosterone secretion in response to stress have been reported. In addition, stress associated mental disorders such as borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD) are characterized by alterations in basal testosterone metabolism. However, testosterone changes to stress have not been investigated in mental disorders such as BPD and PTSD so far.
methodsIn the study described, we investigated testosterone reactivity to an acute psychosocial stressor, the Trier Social Stress Test (TSST). Our sample consisted of young adult women with BPD (n = 28), PTSD (n = 22) or both disorders (n = 22), and healthy control (n = 51). Based on previous studies on basal testosterone secretion in these disorders, we expected the stress-associated testosterone reactivity to be higher in the BPD group and lower in the PTSD group, when compared to the healthy control group.
resultsThe study could demonstrate an increase in testosterone after acute stress exposure across all groups and independent of BPD or PTSD status. Different possible explanations for the absence of a group effect are discussed.
conclusionsFrom the results of this study, we conclude that stress-related changes in testosterone release are not affected by BPD or PTSD status in a female patient population. This study expands the knowledge about changes in gonadal hormones and stress reactivity in these disorders.
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