Trial reportBMC musculoskeletal disorders2021
Effects of tourniquet use on clinical outcomes and cement penetration in TKA when tranexamic acid administrated: a randomized controlled trial.
Trial report in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Total knee arthroplasty with or without a tourniquet: a meta-analysis of randomized controlled trials.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Pooled it
- Impact of tourniquet during total knee arthroplasty when tranexamic acid was used: a meta-analysis of randomized controlled trials.Journal of orthopaedic surgery and research · 2022Pooled it
- Association of Use of Tourniquets During Total Knee Arthroplasty in the Elderly Patients With Post-operative Pain and Return to Function.Frontiers in public health · 2022Pooled it
- Comparing different timings of tourniquet application in total knee arthroplasty: effects on postoperative pain and bone cement interface.Journal of orthopaedic surgery and research · 2025Trial
- Tourniquet Effect on Patients Undergoing Total Knee Arthroplasty: A Single-Blind, Randomized Controlled Trial.Orthopaedic surgery · 2024Trial
- Blood-conserving and therapeutic efficacy of intravenous tranexamic acid at different time points after primary total knee arthroplasty with tourniquet application: a randomised controlled trial.BMC musculoskeletal disorders · 2023Trial
- BACTERIAL COLONIZATION IN ORTHOPEDIC SURGICAL TOURNIQUETS: A MULTICENTER STUDY.Acta ortopedica brasileira · 2026Article
- Results of Total Knee Arthroplasty with Robotic Assistance.Revista brasileira de ortopedia · 2025Article
- [Results of Total Knee Arthroplasty with Robotic Assistance].Revista brasileira de ortopedia · 2025Article
- Review
- Tourniquet effect on cement penetration in total knee arthroplasty: A systematic review and meta-analysis.Journal of experimental orthopaedics · 2025Article
- Application and research progress of tranexamic acid in the perioperative period of posterior lumbar interbody fusion.Frontiers in medicine · 2025Review
- Can We Forgo the Use of Tourniquets in Total Knee Arthroplasty?Revista brasileira de ortopedia · 2024Article
- The mid-term and long-term effects of tourniquet use in total knee arthroplasty: systematic review.Journal of experimental orthopaedics · 2022Review
- Tourniquet application in primary total knee arthroplasty for osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.Frontiers in surgery · 2022Review
- Defining tourniquetless total knee arthroplasty: A systematic review.Journal of orthopaedicsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe role of a tourniquet is still controversial for patients undergoing total knee arthroplasty (TKA). Our current study was performed to determine whether the nonuse of the tourniquet combine with tranexamic acid (TXA) application in TKA patients with end-stage osteoarthritis would accelerate the perioperative recovery rate and provide enough cement mantle thickness for implant fixation.
methodsIn this prospective, randomized controlled trial, 150 end-stage knee osteoarthritis patients receiving TKA were divided into three groups: group A (tourniquet group), group B (non-tourniquet group), and group C (tourniquet in cementation group). All enrolled patients received 3 g of intravenous TXA and 1 g topical TXA. The primary outcomes included blood loss variables and transfusion values. The secondary outcomes included VAS pain score, inflammatory factors level, range of motion, HSS score, postoperative hospital stay, and complication. Furthermore, by using a digital linear tomosynthesis technique, tibial baseplate bone cement mantle thickness was measured in four zones based on the knee society scoring system.
resultsNo significant difference was found among the three groups with regards to total blood loss, transfusion, and complication. However, patients in group B showed lower inflammatory factors levels, shorter length of hospital stay, better range of motion, and lower postoperative pain. No significant difference was found among the three groups in four zones in terms of bone cement mantle thickness.
conclusionsFor end-stage knee osteoarthritis patients, the absence of tourniquet did not appear to affect blood loss and cement penetration in TKA patients. Furthermore, less inflammation reaction and better knee function can be achieved without a tourniquet. We recommend no longer use a tourniquet in primary TKA for patients with end-stage osteoarthritis when TXA is administrated.
trial registrationChiCTR-INR-16009026 . LEVEL OF EVIDENCE: Therapeutic Level I.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.