ArticleStress (Amsterdam, Netherlands)2021
Sex- and stress-dependent effects of a single injection of ketamine on open field and forced swim behavior.
Article in Stress (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- "Chemical Seduction": a narrative review of the complex impact of recreational drugs on sexual function.International journal of impotence research · 2026Review
- KETAMIR-2, a new molecular entity and novel ketamine analog.Frontiers in pharmacology · 2025Article
- Neuroplasticity and Mechanisms of Action of Acute and Chronic Treatment with Antidepressants in Preclinical Studies.Biomedicines · 2024Review
- Pre-adolescence repeat exposure to sub-anesthetic doses of ketamine induces long-lasting behaviors and cognition impairment in male and female rat adults.IBRO neuroscience reports · 2024Article
- Transcriptional signatures of early-life stress and antidepressant treatment efficacy.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Impact of ketamine administration on chronic unpredictable stress-induced rat model of depression during extremely low-frequency electromagnetic field exposure: Behavioral, histological and molecular study.Brain and behavior · 2023Article
- The role of BDNF in mediating the prophylactic effects of (R,S)-ketamine on fear generalization and extinction.Translational psychiatry · 2022Article
- Exploring pharmacological options for adolescent depression: a preclinical evaluation with a sex perspective.Translational psychiatry · 2022Article
- Encore: Behavioural animal models of stress, depression and mood disorders.Frontiers in behavioral neuroscience · 2022Review
- Ketamine Produces a Long-Lasting Enhancement of CA1 Neuron Excitability.International journal of molecular sciences · 2021Article
- Repeated Dosing of Ketamine in the Forced Swim Test: Are Multiple Shots Better Than One?Frontiers in psychiatry · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Ketamine has emerged as a novel treatment for common psychiatric conditions such as Major Depressive Disorder (MDD) and anxiety disorders, many of which can be initiated and exacerbated by psychological stress. Sex differences in the frequency of both anxiety and depressive disorders are well known and could be due to sex differences in neuroendocrine responses to stress. Ketamine is known to modulate the hormonal response to stress, specifically corticosterone. It is not clear if the acute effect of ketamine on corticosterone differs by sex, or what role this could play in subsequent behavior. Here we test whether a single injection of (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.