ArticleGlobal spine journal2023
Hypoalbuminemia and Elevated CRP are Risk Factors for Deep Infections and Urinary Tract Infections After Lumbar Spine Surgery in a Large Retrospective Patient Population.
Article in Global spine journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Comparative assessment of surgical outcomes and cost-efficiency between orthopedic surgeons and neurosurgeons in degenerative lumbar spine surgery: a systematic review with pairwise and proportional meta-analysis.Neurosurgical review · 2025Pooled it
- Development and internal validation of a nomogram for predicting postoperative bone nonunion in infectious spondylitis: a retrospective cohort study.Annals of medicine · 2026Article
- Development of Machine Learning Models for Predicting Surgical Site Infection After Spinal Surgery.Journal of clinical medicine · 2026Article
- Postoperative C-Reactive Protein Trajectories in Spine Surgery - Influence of Vancomycin Powder: A Secondary Analysis of a Prospective Randomized Controlled Trial.Global spine journal · 2026Article
- Association between nadir albumin concentration and mortality in pediatric patients undergoing postcardiotomy extracorporeal membrane oxygenation.Translational pediatrics · 2026Article
- Atrial fibrillation versus non-atrial fibrillation in postoperative complications following lumbar surgery: a retrospective case-control study.Perioperative medicine (London, England) · 2026Article
- Development and Validation of a Preoperative Nomogram for Predicting Prolonged Hospital Stay After Spinal Tuberculosis Surgery.Infection and drug resistance · 2026Article
- Clinical efficacy of one-hole split endoscopy vs. unilateral biportal endoscopy for the treatment of single-segment lumbar spinal stenosis: a retrospective study with 2-year follow-up.Frontiers in surgery · 2025Article
- A comparative study on nosocomial and community-acquired bacterial urinary tract infections: prevalence, antimicrobial susceptibility pattern, and associated risk factors among symptomatic patients attending Hiwot Fana Comprehensive Specialized University Hospital, Eastern Ethiopia.Frontiers in epidemiology · 2025Article
- The role of the medial head of the gastrocnemius myocutaneous flap transfer in the management of prosthesis exposure and deep joint infection following total knee arthroplasty.Archives of orthopaedic and trauma surgery · 2024Article
- Preoperative Albumin and Postoperative CRP/Albumin Ratio (CARS) are Independent Predictive Factors in Estimating 1-Year Mortality in Patients Operated for Proximal Femoral Metastasis with Endoprosthesis.Indian journal of orthopaedics · 2024Article
- Common hematological and biochemical parameters for predicting urinary tract infections in geriatric patients with hip fractures.Frontiers in medicine · 2024Article
- Post-operative C-reactive protein and white blood cells changes pattern following spinal deformity surgery and its clinical correlation.Journal of orthopaedic surgery and research · 2023Article
- Association between hypoalbuminemia and complications after degenerative and deformity-correcting spinal surgeries: A systematic review and meta-analysis.Frontiers in surgery · 2022Review
- Bilateral acetabular fracture secondary to high-velocity trauma: A rare case report.Joint diseases and related surgery · 2022Article
- Diagnostic accuracy of C-reactive protein to rule out infectious complications following hip fracture surgery.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designRetrospective cross-sectional study.
objectivesTo determine if pre-operative albumin and CRP can predict post-operative infections after lumbar surgery.
methodsPatients who underwent an anterior lumbar interbody fusion (ALIF), posterior lumbar interbody fusion (PLIF), or lumbar discectomy were identified using a patient record database (PearlDiver) and were included in this retrospective study. Patients were stratified by Charlson Comorbidity Index (CCI) scores and pre-operative albumin and CRP status. Post-operative complications included deep infections and urinary tract infections within 3 months of the surgery and revisions within 1 year of the surgery.
results74,280 patients were included in this study. 21,903 had pre-operative albumin or CRP lab values. 7,191 (33%), 12,183 (56%), and 2,529 (12%) patients underwent an ALIF, PLIF, and a lumbar discectomy, respectively. 16,191 did not have any complication (74%). The most common complication was UTI (16%). Among all patients, hypoalbuminemia was a significant risk factor for deep infection and UTI after ALIF, deep infection, UTI, and surgical revision after PLIF, and deep infection after lumbar discectomy. Elevated CRP was a significant risk factor for deep infection after ALIF, UTI after PLIF, and deep infection after lumbar discectomy in patients with a CCI ≤ 3.
conclusionsPre-operative hypoalbuminemia and elevated CRP were significant risk factors for deep infection, UTI, and/or revision, after ALIF, PLIT, and/or lumbar discectomy. Future studies with a larger population of patients with low albumin and high CRP values are needed to further elaborate on the current findings.
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