Evidence map›Paper›PMID 33517583›Full record

ArticleStatistics in medicine2021

Capturing heterogeneity in repeated measures data by fusion penalty.

Lili Liu, Mae Gordon, J Philip Miller, Michael Kass, Lu Lin, Shujie Ma, Lei Liu

Abstract read
In one paragraph

Article in Statistics in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Regression Trees With Fused Leaves.Statistics in medicine · 2024
    Article
  4. Article
  5. Health Care Provider Clustering Using Fusion Penalty in Quasi-Likelihood.Biometrical journal. Biometrische Zeitschrift · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lili LiuResearch Center for Mathematics and Interdisciplinary Sciences, Shandong University, Qingdao, China.
Mae GordonDepartment of Ophthalmology, Washington University in St. Louis, St. Louis, Missouri, USA.
J Philip MillerDivision of Biostatistics, Washington University in St. Louis, St. Louis, Missouri, USA.
Michael KassDepartment of Ophthalmology, Washington University in St. Louis, St. Louis, Missouri, USA.
Lu LinZhongtai Securities Institute for Financial Studies, Shandong University, Jinan, China.
Shujie MaDepartment of Statistics, University of California, Riverside, Riverside, California, USA.
Lei LiuDivision of Biostatistics, Washington University in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0003-1844-338X

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Ocular Hypertension Treatment Study 20-Year Follow-up: Coordinating Center GrantUG1EY025182 · NEI · WASHINGTON UNIVERSITY · PI GORDON, MAE O · 2015 to 2019
$4.9M
Ocular Hypertension Treatment Study 20-Year Follow-up: Resource Center GrantUG1EY025183 · NEI · WASHINGTON UNIVERSITY · PI KASS, MICHAEL A · 2015 to 2019
$4.0M
Ocular Hypertension Treatment Study 20-Year Follow-up: Clinical Center GrantUG1EY025181 · NEI · WASHINGTON UNIVERSITY · PI GORDON, MAE O · 2015 to 2019
$3.4M
Ocular Hypertension Treatment Study 20-Year Follow-up: Chairman's GrantUG1EY025180 · NEI · WASHINGTON UNIVERSITY · PI KASS, MICHAEL A · 2015 to 2019
$2.2M
Innovative Analytical Methods for Repeated Measures in the OHTS StudyR21EY031884 · NEI · WASHINGTON UNIVERSITY · PI GORDON, MAE O, LIU, LEI · 2020 to 2021
$439k
China Scholarship Council 201806220145NCATS NIH HHS UL1 TR002345NEI NIH HHS R21 EY031884NEI NIH HHS UG1 EY025180NEI NIH HHS UG1 EY025181NEI NIH HHS UG1 EY025182NEI NIH HHS UG1 EY025183
6 · The paper itself

Abstract

In this article, we are interested in capturing heterogeneity in clustered or longitudinal data. Traditionally such heterogeneity is modeled by either fixed effects (FE) or random effects (RE). In FE models, the degree of freedom for the heterogeneity equals the number of clusters/subjects minus 1, which could result in less efficiency. In RE models, the heterogeneity across different clusters/subjects is described by, for example, a random intercept with 1 parameter (for the variance of the random intercept), which could lead to oversimplification and biases (for the estimates of subject-specific effects). Our "fused effects" model stands in between these two approaches: we assume that there are unknown number of distinct levels of heterogeneity, and use the fusion penalty approach for estimation and inference. We evaluate and compare the performance of our method to the FE and RE models by simulation studies. We apply our method to the Ocular Hypertension Treatment Study to capture the heterogeneity in the progression rate of primary open-angle glaucoma of left and right eyes of different subjects.

Indexed as

GlaucomaGlaucoma, Open-AngleBiasComputer SimulationHumansResearch Designfusion penaltyhigh-dimensional dataprecision medicinevariable selection

Identifiers

PMID33517583
PMCPMC8366591

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.