ArticleNeurology and therapy2021
Rivaroxaban in Recurrent Ischemic Stroke Due to Protein S Deficiency: A Case Report.
Article in Neurology and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Protein S deficiency manifesting with cerebral arterial and venous thrombosis in a young female with kissing carotids phenomenon.Thrombosis journal · 2025Review
- Recurrent ischemic strokes caused by hereditary protein S deficiency from a novel PROS1 mutation: a case report.BMC neurology · 2025Article
- Epstein Barr Virus Encephalitis Treated with Intravenous Immunoglobulins and Corticosteroids.Indian journal of pediatrics · 2025Article
- Successful Pregnancy Outcome in a Patient with Recurrent Miscarriage Due to PCOS Complicated by Hereditary Protein C Deficiency.International journal of women's health · 2025Article
- Rivaroxaban in a Child with Inherited Thrombophilia and Stroke - New Kid on the Block.Indian journal of pediatrics · 2024Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Protein S deficiency is a thrombophilia associated with an increased risk of thromboembolism. Previous studies have shown its role as a predisposing factor for venous thromboembolism, but its role in recurrent arterial ischemic stroke remains uncertain. Here we report a patient with recurrent ischemic stroke due to protein S deficiency. Oral anticoagulant treatment with vitamin K antagonist (VKA) drugs is used to treat and prevent thromboembolic events caused by thrombophilia, but it has many limitations, especially in the case of recurrent thromboembolic events. Direct oral anticoagulants (DOACs) have many advantages over VKA. Previous studies have shown that they are safe in cases of thrombophilia, but they are not well studied in recurrent ischemic stroke due to protein S deficiency. In this study our patient was treated with rivaroxaban. Protein S deficiency may be a predisposing factor in recurrent ischemic stroke, and rivaroxaban can be a safe and effective treatment option. Further studies are needed to confirm our findings.
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